RIG-I - Wikipedia
RIG-I is encoded by the DDX58 gene in humans. [9] [15] RIG-I is a helical ATP-dependent DExD/H box RNA helicase with a repressor domain (RD) on the C-terminus that binds to the …
RIGI Gene - GeneCards | RIGI Protein | RIGI Antibody
2024年12月25日 · Among its related pathways are DDX58/IFIH1-mediated induction of interferon-alpha/beta and SARS-CoV-2 Infection. An important paralog of this gene is IFIH1 . …
Science子刊：重大进展！RIG-I激活对免疫检查点阻断发挥抗肿瘤 …
2019年9月21日 · 在人体中，对原发性黑色素瘤样本的转录组分析揭示出ddx58（编码rig-i的基因）的高表达、t细胞受体和抗原呈递途径活性与延长的总体存活期之间 ...
Gene: DDX58 (ENSG00000107201) - Summary - Homo_sapiens
DDX58-201: 4621: 880aa: ENSP00000369212.1 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. A2A376 O95786-A subset of the GENCODE transcript set, …
DDX58(RIG-I)-related disease is associated with tissue-specific ...
DDX58 and IFIH1 are members of the retinoic acid inducible-like receptors (RLR) and recognize exogenous RNA from many viruses, including coronavirus, Zika virus, and rubella. 7,9-11 …
DDX58(RIG-I)-related disease is associated with tissue-specific ...
Results: We have identified a novel DDX58 variant c.1529A>T p.(Glu510Val) that segregates with disease in two families with SGMRT2. Patients in these families have widely variable …
Autophagy︱张志东团队揭示STING1诱导自噬调控RNA病毒感染的 …
接着，作者进一步利用rnai和crispr-cas9技术构建了一系列基因敲低或敲除的细胞系来探究激活sting1的信号分子以及sting1如何激活自噬，鉴定出模式识别受体，即rna传感分子 rig-i （也 …
RIG-I配体通过RIG-I和OAS1/RNase L分别介导的“启动”和“效应”过程 …
2021年7月31日 · 为了探讨 rig-i 对 rig-i 配体诱导的肿瘤细胞死亡的影响，作者首先 利用 crispr-cas9 剪除人黑色素瘤细胞 1205lu 中表达 rig-i、mda5 以及 mavs 蛋白的基因(即 ddx58、ifih1 …
DDX58 and Classic Singleton-Merten Syndrome - PubMed
Results: We demonstrate a DDX58 autosomal dominant gain-of-function mutation, with constitutive upregulation of type I interferon. Conclusions: DDX58 mutations may be …
JASN：刘志红院士团队发现狼疮性肾炎致病新基因DDX58
机制研究发现，ddx58 r109c突变可以解除rig-i蛋白自抑制，上调rig-i蛋白的k63泛素化水平，促进rig-i蛋白形成寡聚体，增强与下游mavs的相互作用，以及促进mavs聚集，从而激活rig-i-mavs介 …