The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the ...

2024年12月24日 · DUSP1 (Dual Specificity Phosphatase 1) is a Protein Coding gene. Diseases associated with DUSP1 include Intellectual Developmental Disorder, X-Linked 108 and Ovarian Cancer. Among its related pathways are MAPK family signaling cascades and ERK Signaling.

2023年11月7日 · DUSP1 protects against AKI by preventing BAX-induced mtDNA leakage and blocking excessive activation of the cGAS-STING signaling axis through JNK dephosphorylation.

双特异性磷酸酶 1： 该基因编码的蛋白质是一种磷酸酶，对酪氨酸和苏氨酸具有双重特异性。编码的蛋白质可以使 MAP 激酶 MAPK1/ERK2 去磷酸化，从而导致其参与多个细胞过程。这种蛋白质似乎在人类细胞对环境压力的反应以及细胞增殖的负调节中发挥重要作用。最后，编码的蛋白质可以使一些实体瘤 ...

DUSP1 regulates the JAK2/STAT3 signaling pathway through targeting miR-21 in cervical cancer cells. Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells.

2021年9月1日 · Particularly, DUSP1 was recognized to negatively regulate immune response by inhibiting pro-inflammatory cytokine production in preceding studies, but it was also found to be essential for T cell activation. As a result, Dusp1 deficiency prevents NFATc1 nuclear translocation and impairs the TCR signaling events [37].

DUSP1 shRNA or nontarget shRNA CAOV3 cells were left untreated or treated with 5µM rapamycin for 20 h prior to being processed for immunofluorescent detection of LC3. Red puncta denote autophagic vesicle structures (upper panel) and quantification of LC3 puncta (lower panel).

Despite unimpaired insulin signalling and glucose homeostasis, Dusp1 −/− mice were resistant to diet-induced obesity due to increased energy expenditure, but they developed glucose intolerance ...

2010年10月4日 · Downregulation of DUSP1 induced changes in the expression levels of genes involved in specific biological pathways, including angiogenesis, MAP kinase phosphatase activity, cell–cell signaling ...

2016年5月27日 · 作为苏氨酸-酪氨酸双特异性磷酸酶家族成员的双特异性磷酸酶-1（dusp1 / mkp1），首先在培养的鼠细胞中被发现。 随后通过使用基因敲除小鼠和基因沉默技术的研究，确定了DUSP1介导的细胞外信号调节蛋白激酶（ERKs）去磷酸化的分子机制。