We annotate experimentally defined DNA-binding domains and conserved DNA-binding domains defined by the InterPro resources PROSITE, Pfam and SMART; examples include the AP2/ERF domain, the ETS domain, the Fork-Head domain, the HMG box and the Myb domain. 1. Predicted DNA-binding domains. Examples: P10103, P46200, Q9SGJ6, P14921, P55317, P30658

2014年10月1日 · DNA- and RNA-binding proteins (DRBPs) constitute a significant fraction of cellular proteins and have important roles in cells. Their functions include control of transcription and translation,...

DNA binding refers to the process where a protein, such as AR, attaches to DNA after undergoing a significant conformational change, which is crucial for its toxic effects in certain systems. AI generated definition based on: Frontiers in Neuroendocrinology, 2011

2024年11月30日 · DNA-binding proteins are proteins that bind to single- or double-stranded DNA, generally in the major groove if the binding is sequence-specific – as with transcription factors that...

All cells encode specific DNA binding proteins that ensure that genetic material is appropriately expressed, replicated, and transmitted from one generation to the next. Mother Nature solved the DNA recognition problem by inventing a handful of protein motifs, including the zinc finger, the helix-turn-helix, and the leucine zipper.

2022年1月27日 · Sequence-specific binding of proteins to DNA is essential for accessing genetic information. We derive a model that predicts an anticorrelation between the macroscopic association and dissociation rates of DNA binding proteins.

Once isolated, the proteins were shown to bind to specific DNA sequences close to the genes that they regulate. The precise DNA sequences that they recognized were then determined by a combination of classical genetics, DNA sequencing, and DNA-footprinting experiments (discussed in …

Understanding the properties of DNA-binding proteins is of major practical importance, since they are used to control the expression of cloned genes. DNA-binding proteins are also important in molecular medicine, especially in such areas as cancer and aging.

Typically, DNA-binding proteins contain a DNA-binding domain which is required for the physical interaction of the protein to DNA, whereas enzymatic or regulatory functions are generally accomplished through separate domains within the protein.

2012年11月21日 · DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression.