Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, albicidin, and ciprofloxacin. The unique ability of gyrase to introduce negative supercoils into DNA at the expense of ATP hydrolysis [1] is what allows …

2023年8月3日 · The thermophilic bacterium Sulfolobus produced DNA gyrase, a “reverse gyrase” that adds positive superhelical twists to DNA in the presence of ATP. Since it is lacking in higher eukaryotes yet necessary for all bacteria, it is a desirable target for antibiotics.

DNA gyrase is an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA. Gyrase belongs to a class of enzymes known as topoisomerases that are involved in the control of topological transitions of DNA.

2024年10月25日 · DNA gyrase is an enzyme in molecular biology that manages DNA topology, playing a role in replication and transcription. It is a target for antibiotic development, and understanding its mechanism offers insights into cellular …

DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials.

DNA gyrase is an essential bacterial enzyme that catalyzes negative supercoiling of plasmid and chromosomal DNA. In the supercoiled state, DNA adopts a branched and interwound conformation that allows the large chromosome to function in the highly constrained space of a …

DNA gyrase is a type II topoisomerase with the unique capacity to introduce negative supercoiling in DNA. In bacteria, DNA gyrase has an essential role in the homeostatic regulation of supercoiling.

DNA gyrase is one of the primary targets of quinolones, broad-spectrum antibacterial agents and are used as a first-line drug for various types of infections. However, currently used quinolones are becoming less effective due to drug resistance.

DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials.

DNA gyrase is an essential bacterial enzyme that introduces negative supercoils into chromosomal and plasmid DNA, playing a crucial role in processes such as DNA replication, chromosome segregation, site-specific recombination, formation of …