2024年12月24日 · DGCR8 (DGCR8 Microprocessor Complex Subunit) is a Protein Coding gene. Diseases associated with DGCR8 include Velocardiofacial Syndrome and Osteopathia Striata With Cranial Sclerosis. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.

2021年6月29日 · In this study, we uncovered a non-canonical function of DGCR8 in DSB repair signaling and tumor radioresistance. In response to IR, the kinase ATM and the deubiquitinase USP51 mediate the...

2025年2月20日 · The Drosha-DGCR8 complex cleaves the hairpin in the DGCR8 mRNA and thus destabilizes the mRNA; DGCR8 stabilizes Drosha protein via protein interaction; this crossregulation between Drosha and DGCR8 may contribute to the control of miRNA biogenesis.

2007年1月28日 · DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell...

2011年5月13日 · DGCR8 is the first example of a heme-binding protein with two endogenous cysteine side chains serving as axial ligands. We further show that native DGCR8 binds heme when expressed in eukaryotic cells. This study provides a chemical basis for understanding the function of the DGCR8-heme interaction in microRNA maturation.

In this complex, Drosha interacts with DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains. By RNAi and biochemical reconstitution, we show that DGCR8 may be an essential component of the pri-miRNA processing complex, along with Drosha.

The DGCR8 (DGCR8 microprocessor complex subunit) is a protein-coding gene located on chromosome 22. DGCR8 (DiGeorge syndrome critical region 8) is a protein crucial for microRNA (miRNA) processing. It is a component of the microprocessor complex, working alongside Drosha, an RNase III enzyme.

DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes. Although our knowledge of pri-miRNA processing has significantly advanced in recent years, the precise role of DGCR …

Dgcr8 knockout strategy has been instrumental in understanding the function of miRNAs in a variety of cells in vitro and in vivo. In this review, we will first give a brief introduction about miRNAs, miRNA biogenesis pathway and the role of Dgcr8 in miRNA biogenesis.

2023年3月21日 · DGCR8 is a double-stranded RNA-binding protein that interacts with Drosha (608828) and facilitates microRNA (miRNA) maturation (summary by Chen et al., 2012).