2007年1月15日 · DAP12 (also known as TYROBP and KARAP) is expressed by NK cells and myeloid cells and mediates signalling for numerous cell-surface receptors expressed by these cells. DAP12 was originally...

DAP12 is a 12 kDa transmembrane protein recently recognized as a key signal transduction receptor element in Natural Killer (NK) cells. It is a disulfide-linked homodimer that non-covalently associates with several activating receptors expressed on NK cells.

Confocal microscopy showed that internalized KIR2DS molecules are recruited to lysosomal compartments independent of DAP12 expression. Our results suggest that in vivo conditions that adversely affect DAP12 expression will indirectly reduce surface expression and stability of …

DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.

2024年7月15日 · DAP12, also known as tyrosine kinase-binding protein (TYROBP), is a transmembrane adapter protein for several immunoreceptors, and expressed in lymphoid and myeloid lineage cells, including natural killer cells, monocytes/macrophages, dendritic cells, osteoclasts, and microglia [1, 2, 3, 4].

2022年8月24日 · TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is expressed in numerous cell types, including peripheral blood monocytes, macrophages, dendritic cells, and osteoclasts, but a …

DAP12 (also called KARAP) is a transmembrane adapter well known for its role in transducing activation signals for an extended array of receptors in NK cells, granulocytes, monocytes/macrophages, and DCs (1, 2). In this issue of the JCI, Takai and colleagues unveil that DAP12-deficient mice exhibit osteopetrosis and demyelinization of the CNS (3).

2000年12月1日 · DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways.

2013年6月1日 · The present review focuses on TREM-2 and DAP12 structure, signal transduction and regulation as well as biological effects of TREM-2/DAP12 complex activation. It also highlights gaps in the understanding of TREM-2/DAP12 molecular interactions which suggest future directions in the field.

Our findings thus suggest that DAP12 and its associating molecules are differentially regulated by mycobacterial infection and type 1 cytokines and that MDL-1- and TREM-1-triggered DAP12 signaling may play an important role in antimicrobial type 1 immunity.