CYP8B1 is an endoplasmic reticulum membrane protein and catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one.

2024年12月24日 · CYP8B1 (Cytochrome P450 Family 8 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP8B1 include Intrahepatic Cholestasis Of Pregnancy and Extrahepatic Cholestasis. Among its related pathways are Oxidation by cytochrome P450 and Bile acid and bile salt metabolism.

2025年2月19日 · Title: Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.

Sterol 12alpha-hydroxylase (CYP8B1) catalyzes cholic acid synthesis in the liver and is feedback inhibited by bile acids. In addition to activating farnesoid X receptor (nuclear receptor subfamily 1H4), bile acids also induce inflammatory cytokines in hepatocytes.

2022年9月1日 · Cytochrome P450 8B1 (CYP8B1), which synthesizes CA, was induced in livers of colitic mice. CA-treated or liver Cyp8b1-overexpressing mice developed more severe colitis with compromised repair of the mucosal barrier, whereas Cyp8b1-knockout mice were resistant to …

2025年3月8日 · Title: Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption. Absence of Cyp8b1 results in improved glucose tolerance, insulin sensitivity, and beta-cell function, mediated by absence of cholic acid in Cyp8b1(-/-) mice.

We show that ablating Cyp8b1, thereby eliminating 12α-hydroxylated BAs (26), leads to reduced absorption of dietary triglyceride, with intact triglyceride hydrolysis. This prevents Western diet-induced body weight gain, fat accumulation, and steatosis and improves insulin sensitivity.

2024年10月16日 · Sterol 12α-hydroxylase (CYP8B1) is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along the bile acid (BA) synthesis pathway.

2022年9月1日 · They find that the hepatic CYP8B1-cholic acid metabolic axis impairs Lgr5+ intestinal stem cell renewal by repressing PPARα, thus exacerbating intestinal injury. Hepatic FXR activation or CYP8B1 knockout restores damaged epithelial barrier and alleviates colitis.

2025年1月4日 · Clinical resource with information about CYP8B1, Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.