Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene. [5][6][7] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The …

2024年12月24日 · CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Embryonal Carcinoma and Acute …

The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA) metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 family enzymes, …

CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia. Primary metabolites of all-trans-retinoic acid formed by …

As a first step in understanding the developmental function of RA-metabolizing enzymes, we have disrupted the murine Cyp26A1 gene. We report that Cyp26A1 -null mutants die during mid-late …

This manuscript reports the discovery of a mechanism that links two major cellular pathways, retinoic acid (RA) and WNT signaling, which are involved in colorectal cancer (CRC) …

2025年2月8日 · Cyp26a1, which encodes a key enzyme for catabolic inactivation of retinoic acid (RA) required for tight control of local RA concentrations, is significantly downregulated in …

2024年3月5日 · CYP26A1 Is a Novel Cancer Biomarker of Pancreatic Carcinoma: Evidence from Integration Analysis and <i>In Vitro</i> Experiments. Yu Y, Wang Y, Zou Y, Yu YYu Y, et al . …

The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have biologic activity. Hence, CYP26A1, …

Cytochrome P450 26A1 (cyp26a1), a retinoic acid (RA)-metabolizing enzyme, is involved in VA metabolism. It has been shown that cyp26a1 is expressed in female reproductive tract, …