Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying ...

2023年7月25日 · Cyclic adenosine monophosphate is a small, hydrophilic molecule commonly known as cyclic AMP or cAMP, which is an important intracellular second messenger molecule regulated in many physiological processes.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958).

Cyclic adenosine monophosphate (cAMP) is a cyclic nucleotide that functions as a key mediator of extracellular detection in a variety of signaling pathways, including glycogen metabolism, gene regulation, and olfactory sensory transduction.

This review will provide clinicians with an overview of the cyclic AMP axis, its role as a down-regulator of host antimicrobial defense functions, and the clinical and translational relevance of such actions.

Cyclic AMP, formed from ATP by the action of adenylate cyclase, is increased in chondrocytes following mechanical stimulation.

Action of cyclic AMP. Cyclic AMP doesn't act directly on its target enzymes; for example, glycogen phosphorylase and glycogen synthase. Instead, cyclic AMP stimulates a protein kinase cascade that ultimately leads to a cellular response.

2022年3月6日 · Adenosine 3′,5′-cyclic monophosphate (cAMP) is a nucleotide that acts as a key second messenger in numerous signal transduction pathways. cAMP regulates various cellular functions, including cell growth and differentiation, gene transcription and protein expression.

2024年4月6日 · The first second messenger to be identified, cyclic adenosine 3′,5′-monophosphate (cAMP) performs key functions in cellular responses to numerous hormones and neurotransmitters (Sutherland and Rall 1958).

This article reviews the anatomy of the cAMP axis, the mechanisms by which it controls phagocyte immune function, microbial strategies to dysregulate it, and its clinical relevance.