Curacin A is a hybrid polyketide synthase (PKS)/nonribosomal peptide synthase (NRPS) derived natural product produced isolated from the cyanobacterium Lyngbya majuscula. [1] Curacin A belongs to a family of natural products including jamaicamide, mupirocin, and pederin that have an unusual terminal alkene .

Curacin A (Figure 3) is a mixed PK/NRP natural product with potent antiproliferative and antimitotic activity against colon, renal, and breast-cancer-derived cell lines. 93 The compound was originally isolated from strains of the tropical marine cyanobacterium Lyngbya majuscula discovered in Curaçao by Gerwick et al. 94 and was found to ...

Curacin A | C23H35NOS | CID 5281967 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2004年8月3日 · Curacin A (1) is a potent cancer cell toxin obtained from strains of the tropical marine cyanobacterium Lyngbya majuscula found in Curaçao. Its structure is unique in that it contains the sequentia...

Since the isolation of the antimitotic marine natural product curacin A in 1994, synthetic work on this colchicine-site binding agent has been intense, but only recently have synthetic derivatives been identified that match its potency for tubulin polymerization inhibition and its high level of growth inhibition in cancer cell lines.

1994年3月1日 · Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula. Journal of Natural Products 2004 , 67 (8) , 1356-1367.

1995年5月1日 · A concise total synthesis of (+)-curacin A, a novel cyclopropyl-substituted thiazoline from the cyanobacterium Lyngbya majuscula. Tetrahedron Letters 1998 , 39 (18) , 2861-2864.

1997年8月11日 · The total synthesis of curacin A, a cytotoxic agent that interacts with the colchicine binding site on tubulin, is described. The convergent synthesis utilizes natural product and chiral pool starting materials (geraniol, serine) and asymmetric synthesis (chiral allylborane addition, Charette cyclopropanation) to procure the various chiral ...

Curacin A (1) is a potent cancer cell toxin obtained from strains of the tropical marine cyanobacterium Lyngbya majuscula found in Curaçao.

Curacin A (Fig. 10 A) is an antiproliferative and cytotoxic compound synthesised by the tropical marine cyanobacterium L. majuscula. It has been shown to block cell cycle progression by interacting with the colchicine binding site on tubulin and inhibiting microtubule polymerisation (Blokhin et al., 1995). The microtubule network controls ...