2024年12月24日 · CUL5 (Cullin 5) is a Protein Coding gene. Diseases associated with CUL5 include Molluscum Contagiosum and Autism Spectrum Disorder. Among its related pathways are Class I MHC mediated antigen processing and presentation and Infectious disease.

Cullin-5 is a protein that in humans is encoded by the CUL5 gene. [5][6][7] The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone arginine vasopressin.

2024年1月19日 · Here authors identify Cul5, a ubiquitin E3 ligase as an important inhibitor of CD8 + T cell anti-tumour cytotoxicity and persistence via involvement with both T cell receptor and cytokine ...

2020年12月1日 · Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS.

2022年5月19日 · Here, we show that the E3 ubiquitin ligase Cul5 determines fate selection in CD4 + T cells by regulating IL-4 receptor signaling. Mice lacking Cul5 in T cells develop Th2 and Th9 inflammation...

2024年12月10日 · We find that genetic ablation of CUL5, encoding a core element of the multi-protein E3 ubiquitin-protein ligase complex, cullin-RING ligase 5, enhances human CD19 CAR T cell expansion potential...

2016年3月9日 · Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.

Here using mouse models we find that Cullin5 (CUL5), a key component of Cullin-RING E3 ubiquitin ligase 5, is upregulated and associated with increased neutrophil count and influenza-induced exacerbations of house dust mite-induced asthma.

Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS.

最近，有研究人员报道了E3连接酶亚单元Cullin 5（CUL5）的缺失能够促进染色体的不稳定性，并且可以作为ccRCC的一个独立的阴性预后因素。 研究人员指出，CUL5最初是从RNA干扰筛选中鉴定的，并且是一个新的中心体复制控制调控因子。