
CUL5 Gene - GeneCards | CUL5 Protein | CUL5 Antibody
2024年12月24日 · CUL5 (Cullin 5) is a Protein Coding gene. Diseases associated with CUL5 include Molluscum Contagiosum and Autism Spectrum Disorder. Among its related pathways are Class I MHC mediated antigen processing and presentation and Infectious disease.
CUL5 - Wikipedia
Cullin-5 is a protein that in humans is encoded by the CUL5 gene. [5][6][7] The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone arginine vasopressin.
The CUL5 E3 ligase complex negatively regulates central signaling ...
2024年1月19日 · Here authors identify Cul5, a ubiquitin E3 ligase as an important inhibitor of CD8 + T cell anti-tumour cytotoxicity and persistence via involvement with both T cell receptor and cytokine ...
Cullin-RING Ligase 5: Functional characterization and its role in …
2020年12月1日 · Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS.
The ubiquitin ligase Cul5 regulates CD4 - Nature
2022年5月19日 · Here, we show that the E3 ubiquitin ligase Cul5 determines fate selection in CD4 + T cells by regulating IL-4 receptor signaling. Mice lacking Cul5 in T cells develop Th2 and Th9 inflammation...
Cullin-5 deficiency promotes chimeric antigen receptor T cell …
2024年12月10日 · We find that genetic ablation of CUL5, encoding a core element of the multi-protein E3 ubiquitin-protein ligase complex, cullin-RING ligase 5, enhances human CD19 CAR T cell expansion potential...
The role of cullin 5-containing ubiquitin ligases - Cell Division
2016年3月9日 · Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.
Nature Communications丨Cullin5通过调节肺泡巨噬细胞的抗病毒 …
Here using mouse models we find that Cullin5 (CUL5), a key component of Cullin-RING E3 ubiquitin ligase 5, is upregulated and associated with increased neutrophil count and influenza-induced exacerbations of house dust mite-induced asthma.
Cullin-RING Ligase 5: Functional characterization and its role ... - PubMed
Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS.
Oncogenesis:Cullin 5是肾细胞肿瘤中的一个新的候选肿瘤抑制因 …
最近,有研究人员报道了E3连接酶亚单元Cullin 5(CUL5)的缺失能够促进染色体的不稳定性,并且可以作为ccRCC的一个独立的阴性预后因素。 研究人员指出,CUL5最初是从RNA干扰筛选中鉴定的,并且是一个新的中心体复制控制调控因子。
- 某些结果已被删除