2024年12月24日 · CSF2RB (Colony Stimulating Factor 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with CSF2RB include Surfactant Metabolism Dysfunction, Pulmonary, 5 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are TGF-Beta Pathway and MAPK family signaling cascades.

2022年4月28日 · CSF2RB effectively predicted the prognosis of patients with lung adenocarcinoma which could also be a potential target for cancer treatment and prevention. However, further studies are required to elucidate the function and regulatory mechanisms of CSF2RB and to develop some novel treatment strategi …

2011年2月7日 · CSF2RA, located on chromosome X, is a 400 amino acid heterodimeric receptor consisting of a major binding subunit (CSF2RA) and a major signaling subunit (CSF2RB) that regulates differentiation, survival, and proliferation of colony unit forming granulocyte/macrophage progenitor cells by binding to GMCSF (Fig. 3 E).

Colony-stimulating factor 2 receptor beta (CSF2RB) is on chromosome 22 and encodes the β chain of the GM-CSF receptor. It is the shared subunit βc of interleukin 3 (IL3), GM-CSF, and the IL5 receptor.

In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals ...

2022年12月1日 · Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5.

2016年4月27日 · Here we describe the first case of a leukemia patient harboring a germline, CSF2RB-activating point mutation (R461C) and identify small-molecule inhibitors with therapeutic potential against...

2022年12月2日 · Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5.

2025年1月4日 · Title: Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.

2024年4月11日 · Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer. The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor β- Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns.