2024年12月24日 · CRYAB (Crystallin Alpha B) is a Protein Coding gene. Diseases associated with CRYAB include Cardiomyopathy, Dilated, 1Ii and Myopathy, Myofibrillar, 2. Among its related pathways are Cellular responses to stimuli and Cellular response to heat stress.

Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. [5] It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture.

CRYAB is a structural protein of the lens that helps maintain lens transparency. 9 CRYAB is also expressed in non-tissue, including the heart, brain, skeletal muscle, skin, ovaries, and kidneys. 10 – 12 Abnormal expression of CRYAB also occurs in many diseases, such as eye diseases 58, 59 and heart diseases. 60, 61 There is increasing ...

晶状体蛋白α B： 哺乳动物晶状体蛋白分为α、β和γ家族。 α-晶状体蛋白由两种基因产物组成：α-A 和 α-B，分别代表酸性和碱性。 α 晶状体蛋白可由热休克诱导，是小热休克蛋白 (HSP20) 家族的成员。它们充当分子伴侣，尽管它们不会使蛋白质复性并以真正的伴侣的方式释放它们；相反，它们 …

2024年9月2日 · CRYAB（Alpha B-Crystallin）是一种小分子热休克蛋白，属于小热休克蛋白（sHS. Ps）家族。CRYAB在多种细胞类型中表达，尤其在眼睛晶状体、心脏和骨骼肌中. 表达量高。作为一种分子伴侣，CRYAB在应激条件下发挥关键保护作用，防止蛋. 白质聚集和变性。

2025年2月9日 · Title: CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1.

αB-晶状体蛋白(alphaB-crystallin，CRYAB)是小分子热休克蛋白家族中的一员，其功能是作为分子伴侣保护蛋白质不被聚集、保护细胞不受氧化应激等损伤 。 研究发现CRYAB在某些肿瘤类型中高表达，如肺癌、胃癌、结直肠癌、骨肉瘤、卵巢癌等 [ 2 , 3 , 4 , 5 , 6 ] ；而在 ...

cryab是小型热休克蛋白家族的成员，该家族首次发现于眼睛的晶状体中，并涉及多种疾病，例如眼和心脏病，甚至癌症，例如乳腺癌，肺癌，前列腺癌和卵巢癌。

2019年5月30日 · This article reviews the regulation of CRYAB in the apoptotic inflammatory signaling pathway and its role in cancers progression and as a key role in anti-cancer therapy targeting CRYAB in an effort to improve outcomes for patients with metastatic disease.

在此我们利用基因芯片和生物信息学探索Cryab促进肝癌侵袭与转移复发的分子机制；应用免疫共沉淀结合液相质谱分析、RNA干扰分子生物学技术等确定Cryab促肝癌侵袭转移的信号通路后,我们进一步研究Cryab表达与肝细胞癌患者索拉非尼疗效之间的关系。