Dec 24, 2024 · CREB5 (CAMP Responsive Element Binding Protein 5) is a Protein Coding gene. Diseases associated with CREB5 include Inflammatory Bowel Disease 2 and Trichuriasis. Among its related pathways are PI3K-Akt signaling pathway and Toll-like receptor signaling pathway.

新型番荔枝酰胺衍生物（FLZ）能增强BDNF/TrkB/CREB等信号通路， 活化CREB，上调BCL-2，下调BAX并抑制caspase-3的活性，从而 抑制淀粉样前体蛋白（APP）/早老素（PS1）转基因大鼠海马神经元凋亡。 人类的 CCL3L1 （CC ligand 3-like protein 1；a member of the CC chemokine family）通过PKA和CaMKV/CaMKIV 信号通路 激活CREB， 上调BCL-2，可抑制由gp120蛋白诱导的神经元凋亡。

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. [5] [6] [7] The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains.

Feb 28, 2024 · CREB5, also known as CREB-BPA, belongs to the CREB (cAMP response element-binding protein) protein family, which is known to regulate cell growth, proliferation, and differentiation by binding to...

Broad expression in gall bladder (RPKM 3.3), brain (RPKM 3.0) and 22 other tissues. 该基因的产物属于 CRE (cAMP 反应元件) 结合蛋白家族。 该家族的成员包含锌指和 bZIP DNA 结合域。 编码的蛋白质作为同二聚体或异二聚体与 c-Jun 或 CRE-BP1 特异性结合 CRE，并作为 CRE 依赖性反式激活剂发挥作用。 已经鉴定出编码不同亚型的选择性剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The product of this gene belongs to the CRE (cAMP response element)-binding protein …

CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer. High CREB5 expression is associated with proliferation, metastasis and migration of colorectal cancer.

Jul 30, 2024 · Creb5（cAMP responsive element binding protein 5）是一种转录因子，属于CREB/ATF家族。Creb5通过结合cAMP响应元件（CRE）来调控基因表达，在多种生物过程中发挥重要作用，包括细胞增殖、分化和凋亡。

Oct 10, 2024 · Title: RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins. Identification of CREB5 as a prognostic and immunotherapeutic biomarker in glioma through multi-omics pan-cancer analysis.

Aug 25, 2020 · Our study demonstrates a crucial role for CREB5 in CRC metastasis by directly upregulating MET expression. CREB5 may be both a potential prognostic marker and a therapeutic target to effectively overcome metastasis in CRC.

Feb 8, 2025 · 该研究揭示了内质网应激（ERS）相关超级增强子（SE）通过 CREB5 介导激活 TNC 促进肝癌上皮 - 间质转化（EMT）的新机制，为深入理解肝癌进展机制及开发潜在治疗靶点提供了重要依据，对肝癌的防治研究具有关键意义。 肝癌是一种常见的恶性肿瘤，预后较差，其高复发和转移率严重威胁患者生命健康。 深入探究肝癌肿瘤生长和转移的分子机制至关重要。 ERS 是由于内质网中未折叠或错误折叠蛋白积累引发的一种细胞应激反应，可激活未折叠蛋白反 …