2012年9月30日 · We show that convergent transcription induces transcriptional gene silencing (TGS) in trans for both fission yeast and mammalian cells. This method has advantages over existing strategies...

Interestingly, convergent transcription that would direct RNA polymerases into one another does not increase chromosome breakage. In contrast, divergent transcription that would create underwound (potentially single-stranded) DNA does cause …

We demonstrate that convergent transcription of a variety of test gene fragments transfected into S. pombe or mammalian cell lines induce trans TGS through a nuclear RNAi pathway (Fig. 7c). This predicts that long dsRNAs derived from CT plasmids, are …

2025年1月6日 · Here we show that convergent transcription marks an unexpected positively co-regulated promoter constellation. By assessing transcriptional dynamic systems, we identified co-regulated...

Here, we report that simultaneous sense and antisense transcription (convergent transcription) initiated from two inducible promoters flanking a CAG 95 tract in a nonessential gene enhances repeat instability synergistically, arrests the cell cycle, and …

In this article, we wish to define transcriptional interference (TI) specifically as the suppressive influence of one transcriptional process, directly and in cis on a second transcriptional process.

2011年6月7日 · Convergent transcription from two opposing promoters of partially overlapping genes on opposite strands of DNA gives rise to transcripts with potential sense–antisense interactions in the overlapping region.

2024年4月17日 · Loci that produce both sense and antisense transcripts are often referred to as bidirectionally transcribed genes, with additional descriptors such as convergent or divergent, head-to-head or...

Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single-stranded DNA targets.

Pannunzio and Lieber demonstrate that, in wild-type cells, divergent, but not convergent, transcription increases genome instability measured by gross chromosomal rearrangements. For convergent promoters, the function of topoisomerase II is critical for preventing instability at convergent promoters.