2020年5月5日 · Secondly, considering a target of 50% fT > MIC, similar results were obtained with both extended infusion (EI) over 4 h and CI (i.e., MIC up to 1 and up to 2 mg/L for both modes of infusion with 1 g/8 h and 2 g/8 h, respectively), which are close to our results with EI over 3 h (i.e., MICS up to 0.5 and up to 1 mg/L with 1 g/8 h and 2 g/8 h, respectively) [].

2006年2月13日 · Introduction In seriously infected patients with acute renal failure and who require continuous renal replacement therapy, data on continuous infusion of ceftazidime are lacking. Here we analyzed the pharmacokinetics of ceftazidime administered by continuous infusion in critically ill patients during continuous venovenous haemodiafiltration (CVVHDF) in …

2000年3月16日 · Fifteen patients were randomized to receive meropenem either as a 2 g iv loading dose followed by a 3 g continuous infusion (CI) over 24 h or as intermittent administration (IA) of 2 g iv every 8 h (98 h). Each regimen was performed over a period of 2 days followed by a cross over to the alternative regimen for the same time.

2013年1月30日 · Introduction Etomidate is no longer administered as a continuous infusion for anesthetic maintenance or sedation, because it results in profound and persistent suppression of adrenocortical steroid synthesis with potentially lethal consequences in critically ill patients. We hypothesized that rapidly metabolized soft analogues of etomidate could be developed that do …

2004年3月15日 · We randomized 20 critically ill patients with ICU-acquired pneumonia to receive imipenem either 2 g/24 hours by continuous infusion (CON, n = 10) or bolus dosing (1 g every 8 hours) (BOL, n = 10). In both groups, a loading dose of 1 g imipenem was administered, which was followed by continuous infusion or further bolus treatment 4 hours after ...

2008年5月14日 · Remifentanil has a context-sensitive half-time of 3 to 4 minutes, regardless of the duration of infusion, whereas continuous infusion of the other opioids results in accumulation and considerable prolongation of effect, making these opioids intermediate-acting or long-acting agents, depending on the duration of infusion.

2008年5月14日 · Critically ill patients are often treated with continuous intravenous infusions of sedative drugs. However, this is associated with high risk for over-sedation, which can result in prolonged stay in the intensive care unit. Recently introduced protocols (daily interruption and analgosedation) have proven to reduce the length of intensive care unit stay. To introduce …

2012年8月27日 · I read with interest the article from Chytra and colleagues, who investigated the effectiveness and safety of continuous infusion (CI) of meropenem compared with intermittent infusion (II) in a large cohort (n = 240) of critically ill patients . They found that although clinical cure at the end of therapy was similar between the two strategies ...

2001年3月2日 · There were randomized to receive Cefepim 4 g per day either as a continuous infusion (Group 1, n = 17) or intermittent administration 2 g × 2 (Group 2, n = 17) in combination with amikacin 15 mg/kg/day in the two groups. Patients were significantly comparable in terms of age, sex, initial infection disease, IGS II score and MIC of gram ...

2024年11月21日 · Although only clinical cure was positive result in the continuous vs intermittent infusion group (55.7% vs 50.0%, respectively; P < 0.001), the absolute 90-days mortality (24.9% vs 26.8%, respectively), hospital mortality (23.3% vs 25.0%, respectively) and ICU mortality (17.1% vs 18.4%, respectively) were lower in the continuous infusion group ...