This review describes the interactions of type I collagen with the mineral and the contribution of the orientations of the collagen fibers when the bone is submitted to mechanical forces. Different processes of maturation of collagen occur in bone, which can result either from enzymatic or nonenzymatic processes.

The hydroxyapatite crystals give bones their hardness and strength, while the collagen fibers give them a framework for calcification and gives the bone flexibility so that it can bend without being brittle.

This article summarizes what is known about the cAp-collagen interface in bone and begins with descriptions of the matrix and reinforcement roles in composites, of the phases bounding the interface, of growth of cAp growing within the collagen matrix, and of the effect of intra- and extrafibrilar mineral on determinations of interfacial properties.

Bone collagen structure in normal and pathological tissues is presented using techniques of thin section transmission electron microscopy and morphometry. In pathological tissue, deviations from normal fine structure are reflected in abnormal arrangements of collagen fibrils and abnormalities in fibril diameter.

2024年3月1日 · Disruptions in collagen fiber formation, structure, and function by mutations can lead to a range of bone pathologies, highlighting the importance of collagen in maintaining healthy bone tissue. Collagen mutations can affect the production, assembly, …

Collagen is a protein in the form of fibre and is the body's ‘glue’. It possesses two major properties, great tensile strength and relative inextensibility, and forms the major fibrous component of connective tissue structures, i.e. tendons, ligaments, fascia, …

2005年12月9日 · Different processes of maturation of collagen occur in bone, which can result either from enzymatic or nonenzymatic processes. The enzymatic process involves activation of lysyl oxidase, which leads to the formation of immature and …

Lamellar bone is characterized by the organized arrangement of collagen fibers into layers or lamellae. This arrangement gives lamellar bone greater stiffness compared to the disorganized structure of woven bone.

2023年5月1日 · As a specialized connective tissue, bone is comprised of mainly type 1 collagen fibers and inorganic salts. Type 1 collagen is a non-calcified matrix designed to resist the tension experienced by the weight-bearing functions of bone. It forms from osteoblasts, the main cellular component of bone.

2005年10月1日 · Bone collagen structure in normal and pathological tissues is illustrated using techniques of thin section transmission electron microscopy and computer-assisted analysis. The normal bone collagen types, fibril architecture and diameter are described.