Codon usage bias - PubMed
Codon-usage bias is critical factor determining gene expression and cellular function by influencing diverse processes such as RNA processing, protein translation and protein folding. Codon usage bias reflects the origin, mutation patterns and evolution of the species or genes.
Codon Bias as a Means to Fine-Tune Gene Expression - PMC
Applying Codon Bias as a Means to Improve Protein Production. Codon bias has been studied intensively during the past three decades, and some of the insights gained have been widely applied in biotechnology as a strategy to optimize gene expression for improving protein production rates and yields.
Synonymous but not the same: the causes and consequences of codon bias …
2010年11月23日 · This article assesses the competing models for codon bias, in light of genome-scale and high-throughput data. Despite their name, synonymous mutations have significant consequences for cellular...
What is Codon Bias: Implications in Gene Cloning - GoldBio
Codon bias is a bias for synonymous codons encoding the same amino acid, for example a bias for UUU over UUC when both code phenylalanine. Codon biases have implications in protein expression, and there are considerations for choosing host cells or altering codon sequences.
Codon usage bias | Molecular Biology Reports - Springer
2021年11月25日 · Codon-usage bias is critical factor determining gene expression and cellular function by influencing diverse processes such as RNA processing, protein translation and protein folding. Codon usage bias reflects the origin, mutation patterns and evolution of the species or …
Synonymous but not Silent: The Codon Usage Code for Gene …
Codon usage bias, the preference for certain synonymous codons, is found in all genomes. Although synonymous mutations were previously thought to be silent, a large body of evidence has demonstrated that codon usage can play major roles in determining gene expression levels and protein structures.
Synonymous but not the same: the causes and consequences of codon bias ...
Codon bias plays a critical role in heterologous gene expression. However, there is often a disconnect between technological and evolutionary studies of codon bias – a gap that partly reflects genuine differences between endogenous and heterologous situations.
Codon optimality, bias and usage in translation and mRNA decay
2017年10月11日 · The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome — serves as a secondary genetic...
Codon Usage Bias - an overview | ScienceDirect Topics
Synonymous codons are used with different frequencies, a phenomenon known as codon bias. Codon bias is a defining characteristic of each genome and is maintained by a balance between selection, mutation, and genetic drift [1–3].
Codon usage bias: causative factors, quantification methods and …
2020年8月12日 · In this review, we outline the fundamental concepts of evolution of the genetic code, discuss various factors that may influence biased usage of synonymous codons and then outline different principles and methods of measurement of codon usage bias.
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