2024年12月24日 · CNOT1 (CCR4-NOT Transcription Complex Subunit 1) is a Protein Coding gene. Diseases associated with CNOT1 include Vissers-Bodmer Syndrome and Holoprosencephaly 12 With Or Without Pancreatic Agenesis. Among its related pathways are Gene expression (Transcription) and Deadenylation-dependent mRNA decay.

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene. [5] [6] It is a part of the CCR4-Not complex, which deadenylates mRNAs. [7] CNOT1 acts as a scaffold protein, binding other subunits of the complex. [8] [9] [10]

2020年7月2日 · CNOT1 is a member of the CCR4-NOT complex, which is a master regulator, orchestrating gene expression, RNA deadenylation, and protein ubiquitination. We report on 39 individuals with heterozygous de novo CNOT1 variants, including missense, splice site, and nonsense variants, who present with a clini …

In this study, we addressed the function of the CNOT1 subunit by depleting its expression in HeLa cells. Flow cytometric analysis revealed that the sub G 1 fraction was increased in CNOT1-depleted cells.

2025年2月9日 · the CNOT1-LMNA-Hedgehog signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis.

CCR4-NOT is the main enzyme responsible for mRNA deadenylation, which shortens the poly (A) tail in mRNA, thus leading to mRNA degradation. CNOT1 is expressed in early embryonic development and mediates transcriptional repression (summary by De Franco et al., 2019 and Kruszka et al., 2019).

2020年12月2日 · Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly (A) tails, enabling positive selection. Specifically, the CCR4-NOT complex is...

2024年1月15日 · Contributes to poly (A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex.

Ubiquitous expression in testis (RPKM 56.3), esophagus (RPKM 28.6) and 25 other tissues. 启用犰狳重复域绑定活动；分子衔接活性；和核受体结合活性。 有助于聚 (A) 特异性核糖核酸酶活性。 参与多个过程，包括信号转导的负调节；细胞质 mRNA 加工体组装的正调控；和基因表达的调控。 位于 P 体和胞质溶胶中。 CCR4-NOT 复合体的一部分。 与全脑畸形有关。 [由基因组资源联盟提供，2022 年 4 月]

2023年1月31日 · The largest subunit, CNOT1 (Not1 in yeast), serves as the backbone of the CCR4-NOT complex and interacts with most other core subunits to form distinct structural and functional modules. CNOT1 can be broadly divided into N …