We review the evidence for the existence of clozapine-induced withdrawal symptoms, and in particular focus on withdrawal-associated psychosis, cholinergic rebound, catatonia and serotonergic discontinuation symptoms.

Serotonin syndrome, associated with clozapine withdrawal, can result from the abrupt withdrawal of 5-HT 2A antagonism. 9 The symptoms of serotonin syndrome include, but are not limited to, clonus, hyperreflexia, agitation, restlessness, confusion, muscle rigidity, and diaphoresis. Life-threatening signs and symptoms of serotonin syndrome ...

We review the evidence for the existence of clozapine-induced withdrawal symptoms, and in particular focus on withdrawal-associated psychosis, cholinergic rebound, catatonia and serotonergic discontinuation symptoms.

2024年3月22日 · While it can be highly effective in managing symptoms, discontinuing clozapine can lead to a range of withdrawal effects, including a phenomenon known as cholinergic rebound. Clozapine withdrawal, like withdrawal from many psychotropic medications, can be a challenging and potentially risky process.

Discontinuing clozapine in patients with schizophrenia is associated with an increased risk of relapse of psychotic symptoms. 21, 22 This is particularly problematic in patients with treatment-resistant schizophrenia, as other antipsychotic drugs are unlikely to be effective.

2024年8月15日 · Clozaril Withdrawal Symptoms. In the vast majority of cases, abrupt Clozaril withdrawal is not recommended as it will produce the most severe withdrawal responses. Gradual cessation is recommended to help alleviate this phenomenon. Clozaril withdrawal symptoms can include: Seizure-like reactions* 11

2021年10月15日 · Discontinuing clozapine in patients with schizophrenia is associated with an increased risk of relapse of psychotic symptoms. 21, 22 This is particularly problematic in patients with treatment-resistant schizophrenia, as other antipsychotic drugs are unlikely to be effective.

Abrupt withdrawal of clozapine has been associated with symptoms of “cholinergic rebound,” including nausea, vomiting, hypersalivation, diarrhea, diaphoresis, insomnia, and agitation, as well as rapid onset of psychosis. 1-4 There are comparatively fewer reports of serotonin syndrome associated with the withdrawal of the serotonin receptor ...

2021年8月12日 · Central cholinergic rebound can cause parkinsonian symptoms, ataxia, hypertonia, as well as delirium and psychosis. In rarer cases, withdrawal can lead to serotonin syndrome, seizures, and even catatonia. Clozapine withdrawal has been shown to occur in up to 46% of patients when the drug is suddenly stopped, with varying degrees of severity.

2021年9月18日 · We review the evidence for the existence of clozapine-induced withdrawal symptoms, and in particular focus on withdrawal-associated psychosis, cholinergic rebound, catatonia and serotonergic discontinuation symptoms.