Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene. [5][6] The CKS1B protein binds to the catalytic subunit of the cyclin-dependent kinases and is essential for their biological function.

2024年12月24日 · CKS1B (CDC28 Protein Kinase Regulatory Subunit 1B) is a Protein Coding gene. Diseases associated with CKS1B include Breast Cancer and Leukemia, Acute Lymphoblastic. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Mitotic G1 phase and G1/S transition.

2020年9月9日 · Gains or amplification (amp) of chromosome 1q21/ CKS1B are reported to be a high-risk factor in myeloma. In this retrospective study, we analyzed the impact of CKS1B gain/amp on overall...

CKS1B, the protein encoded by the CKS1 gene on human chromosome Iq21, has a molecular weight of 9 kDa and is highly functionally conserved (5). In early coimmunoprecipitation studies, scholars found that CKS1 tightly bound CDK from yeast, human cells, and frog eggs.

2007年6月1日 · Overexpression of CKS1B, a gene mapping within a minimally amplified region between 153 to 154 Mb of chromosome 1q21, is linked to a poor prognosis in multiple myeloma (MM). CKS1B binds to and activates cyclin-dependent kinases and also interacts with SKP2 to promote the ubiquitination and proteasomal degradation of p27 Kip1.

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein.

Gains or amplification (amp) of chromosome 1q21/CKS1B are reported to be a high-risk factor in myeloma. In this retrospective study, we analyzed the impact of CKS1B gain/amp on overall survival in the context of other genetic aberrations, such as TP53 deletion, FGFR3-IGH, IGH-MAF, MYEOV/CCND1-IGH, a …

Here we demonstrate the crucial role of CKS1B in multiple myeloma (MM) progression and define CKS1B-mediated SKP2/p27 (Kip1)-independent down-stream signaling pathways. Forced-expression of CKS1B in MM cells increased cell multidrug-resistance. CKS1B activates STAT3 and MEK/ERK pathways.

2007年6月1日 · CKS1B binds to and activates cyclin-dependent kinases and also interacts with SKP2 to promote the ubiquitination and proteasomal degradation of p27(Kip1). Overexpression of CKS1B or SKP2 contributes to increased p27(Kip1) turnover, cell proliferation, and a poor prognosis in many tumor types.

2022年11月22日 · As a regulatory subunit of cyclin kinase, CKS1B promotes cancer development and is associated with poor prognosis in multiple cancer patients. However, the intrinsic role of CKS1B in pancreatic cancer remains elusive. In our research, CKS1B ...