Multiple mechanisms contribute to kidney dysfunction following cisplatin administration. Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death.

2021年3月29日 · Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation.

A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal.

This review focuses on the mechanisms of cisplatin-induced acute kidney injury. We will briefly discuss the clinical features of cisplatin-induced AKI followed by a more detailed discussion of the responsible cellular mechanisms, with a particular emphasis …

2022年10月13日 · Renal accumulation of cisplatin leads to a high incidence of acute and chronic nephrotoxicity. Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function...

The pathophysiology of cisplatin-induced AKI involves 4 major mechanisms: (1) proximal tubular injury, (2) oxidative stress, (3) inflammation, and (4) vascular injury in the kidney.

The effectiveness of cisplatin, a mainstay in the treatment of many solid organ cancers, is hindered by dose-limiting nephrotoxicity. Cisplatin causes AKI in 30% of patients. Patients who do not develop AKI by clinical standards during treatment are ...

A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease.

2024年8月27日 · We identified CXCL1 as a potential biomarker of cisplatin-AKI and identified the superior efficacy of UC-MSCs in mitigating cisplatin-AKI. Kidneys are at risk from drug-induced toxicity, with a significant proportion of acute kidney injury (AKI) linked to …

2020年9月1日 · Several studies have reported risk factors for predicting cisplatin-induced acute kidney injury (AKI), including old age, female sex, smoking, hypoalbuminemia, hypokalemia, hypomagnesemia, a high body surface area, advanced cancer and the total dose of …