The cellular inhibitor of apoptosis 2 (cIAP2/HIAP1) is a potent inhibitor of apoptotic death. In contrast to the other members of the IAP family, cIAP2 is transcriptionally inducible by nuclear factor-κB in response to multiple triggers.

ASTX660 antagonizes cIAP-1, ciap-2 and XIAP through binding to BIR3. In vitro evaluation of its efficacy has demonstrated direct XIAP antagonism and depletion of cIAP-1 and cIAP-2 activating the alternative NF-κB pathway and leading to TNF-α dependent apoptosis in MDA-MB-231, HEK293, A375 and SK-MEL-28 cell lines, among others [ 115 ].

In this study, we demonstrated that A20 (also known as TNFAIP3, tumor necrosis factor α-induced protein 3, and an anti-apoptotic protein) regulates the inhibitor of apoptosis protein-2 (cIAP-2) expression upon TNF-α induction in endothelial cells.

2019年5月28日 · Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival.

Cardiac fibroblasts exposed to H2O2 expressed enhanced levels of anti-apoptotic cIAP-2 mRNA and protein, revealed by real time PCR and western blot analysis, respectively.

2011年3月24日 · The cellular inhibitor of apoptosis proteins 1 and 2 (cIAP1 and cIAP2) are members of a highly conserved and critically important family of inhibitor of apoptosis proteins (IAPs) that function...

2020年8月25日 · Expression of cIAP-1 and cIAP-2 mRNA in our patient cohort was associated with advanced disease progression, poor disease outcome, and overall decreased patient survival for breast cancer. cIAP-1 mRNA higher expression could be the predictive marker for the advancement of disease, while cIAP-2 could be the indicator for distant organ metastases.

2014年3月3日 · In this study, we demonstrated that A20 (also known as TNFAIP3, tumor necrosis factor α-induced protein 3, and an anti-apoptotic protein) regulates the inhibitor of apoptosis protein-2 (cIAP-2) expression upon TNF-α induction in endothelial cells.

2013年9月1日 · Cardiac fibroblasts exposed to H2 O 2 expressed enhanced levels of anti-apoptotic cIAP-2 mRNA and protein, revealed by real time PCR and western blot analysis, respectively.

The inhibitors of apoptosis proteins (IAPs) are a recently identified group of antiapoptotic proteins. So far, five members have been identified in human cells: NAIP, cIAP-1, cIAP-2, XIAP and survivin.