Sep 28, 2015 · Indeed, as our analysis demonstrates, 41.3% of patients harboring a homozygous risk allele genotype (CC) at the CFH Y402H locus showed good response with anti-VEGF …

Jun 25, 2020 · Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD). AMD …

Feb 11, 2019 · We show that aged mice expressing the human H402, but not Y402 variant, (i) develop AMD-like symptoms and (ii) display differences in their systemic and ocular lipoprotein …

Nov 8, 2023 · Genetic variants in the gene encoding complement factor H (CFH) have been identified as an AMD susceptibility gene, however, the mechanistic link is debated. Here, we …

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Dec 15, 2013 · Genetic abnormalities within the CFHR gene locus can result in hybrid proteins with affected dimerization or recognition domains which cause defective functions. Here we …

Complement factor H (CFH) is a component of the mammalian complement system, which regulates the alternative pathway of complement activation and protects the host cell from …

Sep 9, 2014 · Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1–5, with …

Sep 18, 2024 · Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Genome-wide association study of …

We perform a study to investigate the CFH /CFHRs gene variants and their roles in IgAN with microangiopathy based on a previous genome-wide association study (GWAS). Methods: We …