Centromere protein F is a protein that in humans is encoded by the CENPF gene. [ 5 ] [ 6 ] [ 7 ] It is involved in chromosome segregation during cell division . It also has a role in the orientation of microtubules to form cellular cilia .

Dec 24, 2024 · CENPF (Centromere Protein F) is a Protein Coding gene. Diseases associated with CENPF include Stromme Syndrome and Corpus Callosum, Agenesis Of. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids.

CENP-F is protein of the nuclear matrix that gradually accumulates during the cell cycle until it reaches peak levels in G2 and M phase cells and is rapidly degraded upon completion of mitosis. CENP-F is first detected at the prekinetochore complex during late G2, and is clearly detectable as paired foci that correspond to all the centromeres ...

Dec 13, 2022 · Here, we show that DRP1 is recruited to the kinetochore by centromeric Centromere protein F (CENP-F) after nuclear envelope breakdown in mouse oocytes. Loss of DRP1 during prometaphase leads...

着丝粒蛋白 f： 该基因编码一种与着丝粒-着丝粒复合体相关的蛋白质。 该蛋白质是间期 G2 期核基质的组成部分。 在 G2 后期，该蛋白质与着丝粒结合，并在早期后期维持这种结合。

CENP-F (D6X4L) Rabbit mAb recognizes endogenous levels of total CENP-F protein. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1794 of human CENP-F protein.

Centromere protein F and survivin are malignant behaviour markers for colorectal gastrointestinal stromal tumours. Data identified Cenp-F as a potential new molecular target for NBPs in tumour cells. Cenp-F plays a role in organization of interphase chromatin through association and possibly regulation of DNA-PK.

Apr 7, 2006 · Centromeric protein F (CENP-F) is a 367-kDa human kinetochore protein that was identified a decade ago, but its function was only recently revealed by studies that used small interfering RNA to deplete the protein from cells.

Jan 5, 2025 · Title: Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways. CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle.

Apr 1, 2007 · Among the genes we identified was centromere protein-F (CENP-F), a gene associated with poor prognosis. In a published follow-up breast cancer DNA microarray study, comprising 295 tumour samples, we found that CENP-F upregulation was significantly associated with worse overall survival (p<0.001) and reduced metastasis-free survival (p<0.001).