2011年9月5日 · Aging Cell is an open access geroscience journal publishing research addressing the biology of aging. The journal welcomes research that reports the mechanistic, molecular, and cellular aspects of the aging process, as well as the links between aging and age-related disease.

Major features of cellular aging. As the cell ages, translational defects and entropy progressively increase the amount of cellular damage, and clearance and quality control mechanisms grow less effective.

2023年1月3日 · We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis.

2021年6月22日 · Cellular aging mechanisms are in place from the day you are born. As cells divide, multiply, and perform their designated functions, they age. And as they age, your body has in place remarkable ways to take care of aging cells and replenish them with new ones. So, what causes cell aging anyway? Here are some of the most common triggers of cell ...

Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease.

Herein, we describe several crucial processes responsible for the regulation of cellular aging, including the essence of carbonylation, its role in perturbing proper protein folding, and its potential value as an aging biomarker.

Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...