CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. It has necessary roles in the formation and stability of microtubules from the centrosome [5] and has been found to be linked to human brain size variation in males. [6]

2024年12月24日 · CDK5RAP2 (CDK5 Regulatory Subunit Associated Protein 2) is a Protein Coding gene. Diseases associated with CDK5RAP2 include Microcephaly 3, Primary, Autosomal Recessive and Microcephaly. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and Cell Cycle, Mitotic.

Here, we identify the mechanism of γTuRC activation by CDK5RAP2 centrosomin motif 1 (CM1).

2025年2月8日 · A novel missense variant in CDK5RAP2 associated with non-obstructive azoospermia. CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma. CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3beta/beta-catenin-WIP1 pathway.

2023年2月11日 · In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully...

2021年12月20日 · Here, we demonstrate that knocking down CDK5RAP2 in human fibroblasts triggers premature cell senescence that is recapitulated in Cdk5rap2an/an mouse embryonic fibroblasts and embryos, which...

2024年9月24日 · We identified an unexpected conformation of the γ-TuRC bound to multiple protein modules containing MZT2, GCP2, and CDK5RAP2, resulting in a long-range constriction of the γ-tubulin ring that brings it in closer agreement with the 13-protofilament microtubule.

2007年10月24日 · We report characterization of CDK5RAP2, a novel centrosomal protein whose mutations have been linked to autosomal recessive primary microcephaly. In somatic cells, CDK5RAP2 localizes throughout the pericentriolar material in all stages of the cell cycle.

2025年1月4日 · Clinical resource with information about CDK5RAP2, Genome-wide association of lipid-lowering response to statins in combined study populations., Microcephaly 3, primary, autosomal recessive, Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans., and available tests.

2018年2月27日 · The CDK5RAP2 gene encodes a centrosomal protein that localizes to the spindle poles during mitosis (summary by Hassan et al., 2007 and Lizarraga et al., 2010).