Aug 9, 2006 · Cdc28 is the catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) (26, 3). Homologs include CDK1 in animals and cdc2 in S. pombe. Waves of CDK activity drive events of the cell cycle through phosphorylation of key substrates (34, 39 and reviewed in 5).

Feb 8, 2025 · Enables RNA polymerase II complex binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone binding activity. Involved in several processes, including nuclear chromosome segregation; regulation of cell cycle process; and regulation of primary metabolic process.

Jun 11, 2012 · Cdc28 initiates the cell cycle by activating cell-cycle–specific transcription factors that switch on a transcriptional program during late G1 phase. Cdc28 also has a cell-cycle–independent, direct function in regulating basal transcription, which does not require its catalytic activity.

The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the most part, remain to be delineated, Cdc28 activity controls the timing of mitotic commitment, bud initiation, DNA replication …

Cdc28 initiates the cell cycle by activating cell-cycle–specific transcription factors that switch on a transcriptional program during late G1 phase. Cdc28 also has a cell-cycle–independent, direct function in regulating basal transcription, which does not require its catalytic activity.

In the budding yeast Saccharomyces cerevisiae, a single Cdk, Cdc28 (which is equivalent to Cdk1 in other organisms), associates with multiple cyclins to regulate the cell cycle. By contrast,...

Jun 26, 2012 · The cyclin-dependent kinase Cdc28 is the master regulator of the cell cycle in Saccharomyces cerevisiae. Cdc28 initiates the cell cycle by activating cell-cycle-specific transcription factors that switch on a transcriptional program during late G1 phase.

Jan 16, 2025 · Cdc28 is a protein kinase in yeast that plays a significant role in regulating the cell cycle and ensuring proper DNA replication. It controls various stages of the cell cycle, making it a focus for researchers aiming to understand cellular division processes.

We show that Cdc28 and the S-phase cyclin Clb6 specifically phosphorylate Swi6 at serine 160 in vitro and also direct nuclear export of Swi6 in vivo. We propose that Clb6 not only facilitates DNA replication but, by stimulating export of Swi6, curtails further G 1 activity.

Aug 3, 1998 · We have examined connections between nutrients, and the expression and activity of Cln3–Cdc28 kinase that regulates the G 1 –S boundary of the cell cycle in yeast, a point referred to as Start. We find that Cln3 protein levels are highest in glucose and lower in poorer carbon sources.