2020年7月30日 · Conventional dendritic cells (cDCs) comprise two subsets, type 1 (cDC1) and type 2 (cDC2). Plasmacytoid DCs (pDCs) are specialized for type I interferon (IFN) secretion. Every subset...

Activated classical dendritic cells (cDCs) travel to the T cell areas of secondary lymphoid tissues to stimulate CD4+ T cells through classical antigen presentation on MHC class II. cDCs can also stimulate CD8+ T cells through classical and cross-presentation pathways.

Accumulating evidence shows that cdc2 not only promotes G 2 ‐M transition but is also capable of regulating G 1 progress and G 1 ‐S transition via association with multiple interphase cyclins; cdc2 activity can be inhibited by p21 and p27, two traditional G 1 CDK inhibitors.

2019年11月19日 · Classical dendritic cells are classified as cDC1 and cDC2 on the basis of their function and dependence on transcription factors. In Cell, Rudensky and colleagues describe two distinct subsets...

2022年6月14日 · The authors demonstrate how cDC1s can “sing” to cDC2s via the IDO1-Kyn-AHR axis to promote conversion to a tolerogenic cDC2 phenotype. This work underscores how the functional phenotype of a specific DC subset can be profoundly modulated by a neighboring DC subset in a paracrine fashion, thereby inducing a phenotypic switch.

2025年2月1日 · Conventional dendritic cells (cDCs) are the professional antigen-presenting cells of the mammalian immune system, and are classified into two primary subsets: cDC1 and cDC2.

We have identified a novel 'Activating factor' that stimulates binding between cyclin and Cdc2 by inducing phosphorylation of Cdc2 on Thr161. We propose that Thr161 is targeted by an additional cell cycle regulatory pathway.

Accumulating evidence shows that cdc2 not only promotes G (2)-M transition but is also capable of regulating G (1) progress and G (1)-S transition via association with multiple interphase cyclins; cdc2 activity can be inhibited by p21 and p27, two traditional G (1) CDK inhibitors.

2023年4月7日 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12),...

We now provide evidence that Cdc2 binds to cyclin E (in addition to cyclin A and B) and is able to promote the G1/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G1/S phase in parallel.