One Week of CDAHFD Induces Steatohepatitis and Mitochondrial ...
2021年5月29日 · Feeding a CDAHFD diet for only 1-week induced lipid droplet deposition in the liver with increasing activity of liver-derived enzymes in the plasma. On the other hand, it did …
A CDAHFD-induced mouse model mimicking human NASH in the …
2024年3月18日 · A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) has recently been used to induce the NASH model, but the advantages are not established. NASH models …
Estimating Drug Efficacy with a Diet-Induced NASH Model in …
In the present study, we developed a choline-deficient, L-amino-acid-defined, high-fat-diet (CDAHFD)-induced human NASH model using human liver chimeric mice. We demonstrated …
Nonobese mice with nonalcoholic steatohepatitis fed on a choline ...
Here, we analyzed the effects of dietary methionine content on NASH induced in mice fed on a choline‐deficient, methionine‐lowered, l ‐amino acid‐defined high‐fat diet (CDAHFD). CDAHFD …
Quantitative, noninvasive MRI characterization of disease progression ...
2021年3月17日 · Mice were fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) to induce NASH with advanced fibrosis. Mice fed normal chow and CDAHFD underwent MRI …
CDAHFD 诱导的小鼠模型在肝磷脂酰胆碱和酰基肉碱的代谢中模拟 …
最近已使用缺乏胆碱、 L-氨基酸限定的高脂肪饮食（CDAHFD）来诱导 NASH 模型，但其优点尚未确立。 NASH模型的诱导使用著名的传统蛋氨酸和胆碱缺乏（MCD）饮食5周，以及最近使 …
Cholesterol overload in macrophages drives metabolic dysfunction ...
2024年11月29日 · CDAHFD-fed mice exhibited local cholesterol accumulation and a pro-inflammatory macrophage phenotype in the liver. Cholesterol overload in vitro promoted M1 …
Establishment and characterization of mouse metabolic …
2024年11月10日 · Organoids were developed using mouse liver tissues subjected to a choline-deficient L-amino acid-defined high-fat diet (CDAHFD) to mimic MASH-related HCC. The …
A researcher’s guide to preclinical mouse NASH models
2022年12月20日 · In this line, preclinical mouse models are crucial tools to investigate mechanisms as well as novel treatment modalities during the pathogenesis of NASH and …
One Week of CDAHFD Induces Steatohepatitis and Mitochondrial ...
These results demonstrated that 1 week of feeding CDAHFD to mice induces steatohepatitis with mitochondrial dysfunction and severe oxidative stress, without fibrosis, which can partially …
非酒精性脂肪肝模型 (NASH)Matsumoto模型饲料法_南通特洛菲饲 …
60%高脂肪0.1%蛋氨酸的胆碱缺乏 (CDAHFD)模型饲料用于非酒精性脂肪肝模型 (NASH)的造模，不仅NASH表现与人类相似，而且具有体重不下降、发展速度快的优点，在肝纤维化研究及 …
胆碱缺乏的L-氨基酸定义的高脂饮食（CDAHFD）诱导的非酒精性 …
已开发出胆碱缺乏氨基酸定义的高脂饮食（CDAHFD）诱导的NASH小鼠模型。 但是，其与人类NASH的相关性，包括血清脂质谱，尚未得到明确定义。 在这项研究中，我们已经发现，饲 …
Reduced Serum Cholesterol and Triglyceride Levels in a Choline ...
In this study, we have revealed that mice fed CDAHFD showed significantly lowerd serum total cholesterol and triglyceride (TG) levels, in addition to reduced body weight (BW). Furthermore, …
An improved mouse model that rapidly develops fibrosis in non …
We aimed to establish a mouse model of NASH with fibrosis by optimizing the methionine content in the HFD. Male mice were fed a choline-deficient, L-amino acid-defined, high-fat diet …
Time-restricted feeding has a limited effect on hepatic lipid ...
2024年1月29日 · Here, we determined whether TRF affects NASH pathology induced by a choline-deficient high-fat diet (CDAHFD), which does not involve obesity. TRF ameliorated the …
Hepatocellular carcinoma in a mouse model fed a choline ... - PubMed
We have previously reported a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) as a dietary NASH model with rapidly progressive liver fibrosis in mice.
Mouse models of nonalcoholic fatty liver disease (NAFLD ...
In this review, we summarize the newly described patho-mechanisms of NAFLD and review the preclinical mouse models of NAFLD (based on the method of induction) and appraises the use …
徳島大学 / 教育研究者総覧 --- 常山 幸一 - Tokushima U
徳島大学 大学院医歯薬学研究部 医学域 医科学部門 病理系 疾患病理学 徳島大学 医学部 医学科 生体防御腫瘍医学講座 疾患 ...
The pharmacodynamic and differential gene expression analysis ... - PubMed
2020年12月16日 · To profile the regulatory network of PPAR α/δ agonist in NASH, the choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) induced NASH model was used to test …