CD5 includes a scavenger receptor cysteine-rich protein domain. T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.

2023年5月25日 · It had been clear, that the antiquated T cell marker CD5 is important for T cell receptor signaling fine tuning and for protection from activation-induced cell death. 2 Historically, CD5 has...

2024年12月24日 · CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymic Carcinoma and Prolymphocytic Leukemia. Among its related pathways are Modulators of TCR signaling and T cell activation and Hematopoietic Stem Cells and Lineage-specific Markers.

CD5 is a specialized type of protein normally found on the surface of immune cells where it is involved in modulating signal transduction pathways. It plays a significant role in regulating immune responses and maintaining the balance between activating and inhibiting signals within the immune system.

CD5 is a molecule involved in signal transduction through tyrosine phosphorylation of intracellular proteins. It plays a role in modulating signaling via antigen-specific receptor complexes in T and B lymphocytes, with high expression on mature T-lymphocytes and low expression on a subset of mature B-lymphocytes.

2018年12月7日 · Here we focus on CD5, a transmembrane receptor that regulates T cell functions and development but remains poorly characterized at the molecular level. We will review its roles in physiological conditions and suggest potential molecular effectors that could account for CD5-dependent regulation of TCR signaling.

CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory function.

CD5 is a scavenger-like receptor expressed in association with the antigen-specific receptors on T and B-1a lymphocytes. Recent studies reveal a broader biology for CD5 that includes its role as regulator of cell death and as a receptor for pathogen ...

2024年6月12日 · CD5 is a critical regulatory molecule in the immune system, involved in modulating T cell and B cell functions, maintaining immune tolerance, and preventing autoimmune responses. Its clinical significance spans autoimmune …

2023年2月17日 · The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs c …