CD49d promotes disease progression in chronic lymphocytic leukemia…
2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to …
CD49d Is a New Marker for Distinct Myeloid-Derived Suppressor …
2010年7月1日 · We found CD49d (VLA4), a member of the integrin α-chain family of proteins, to be exclusively expressed on CD11b + Gr-1 dull/int cells. CD49d is composed of a α4 (CD49d) …
CD Markers - Pathology Outlines - CD49
2025年3月3日 · Persistently reduced expression of blood monocyte CD49e is an adverse prognostic marker in HIV (AIDS 2009;23:2247) Uses by pathologists. No significant clinical …
CD49d Shapes B Cell Receptor Responsiveness and Tissue …
2023年11月2日 · Here, we address the consequences of genetic B cell-specific ablation of CD49d on disease development, engraftment capacity and treatment susceptibility in a novel CLL …
Maturation-Dependent Expression and Function of the CD49d …
2000年10月15日 · CD49d integrin expression conferred mature MDDC with an elevated capacity to adhere to the CS-1 fragment of fibronectin, and also mediated transendothelial migration of …
Relevance of CD49d protein expression as overall survival and ...
2008年1月15日 · CD49d/α4-integrin is variably expressed in chronic lymphocytic leukemia (CLL). We evaluated its relevance as independent prognosticator for overall surviva
CD49d expression is an independent risk factor of progressive disease ...
We analyzed CD49d expression in 140 consecutive Binet A chronic lymphocytic leukemia. At diagnosis, CD49d ≥30% (54/140, 38.6%) associated with proliferation markers, namely CD38 …
CD49d and CD26 are Independent Prognostic Markers for …
In conclusion, surface expression of CD49d and CD26 are independent adverse prognostic markers in patients with CLL at different stages. Therefore, evaluation of CD26 and CD49d …
The pathogenic relevance of the prognostic markers CD38 and CD49d …
2013年11月28日 · A more recently discovered marker is CD49d, the alpha4 subunit of the VLA-4 integrin (alpha4beta1). High CD49d expression predicts reduced overall survival and time to …
CD49d Expression Identifies a Chronic Lymphocytic Leukemia …
2009年11月20日 · In chronic lymphocytic leukemia (CLL), CD49d, often in association with CD38, has been shown to mark a disease subset with poor prognosis. Functionally, both molecules …