2024年12月24日 · CD46 (CD46 Molecule) is a Protein Coding gene. Diseases associated with CD46 include Hemolytic Uremic Syndrome, Atypical 2 and Genetic Atypical Hemolytic-Uremic …

CD46-mediated signals regulate innate and adaptive immune cell function. (a) CD46 modulates innate cell functions. CD46 cross-linking by natural and pathogenic ligands suppresses …

Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b …

CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. CD46 is also used as a receptor by several …

CD46 not only protects cells from complement-mediated attack and facilitates infection by a large number of pathogens, but also exerts complex effects on cellular immune function.

Here, we highlight how the functions of the complement component CD46 have expanded dramatically beyond its initial discovery as a regulator of complement activation.

2015年6月10日 · Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I …

In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of …

CD46 is a type I transmembrane glycoprotein that is expressed on most tissues as four major isoforms derived by alternative splicing of a single gene. The N-terminus of each isoform …

CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. CD46 is also recognized by several human …