Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours.

2024年3月19日 · CD Markers - CD43

CD43 is a single -chain polypeptide expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets, and some B lymphocytes which may be important for cell activation and lymphoid function.

2009年10月22日 · CD43-deficient cells exhibited reduced levels of promyelocytic nuclear bodies and had increased sensitivity to apoptosis induced by growth factor withdrawal or T-regulatory cell suppression. Taken together, our data indicate an essential function of CD43 processing and nuclear localization of CD43ct in cell homeostasis and apoptosis. Topics:

2018年1月1日 · CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP.

2019年6月13日 · In this study we examined the role of CD43 in the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas’ disease, a potential life-threatening illness endemic in ...

CD43 is the major sialic acid rich protein on the surface of lymphocytes. However, the specific roles of this protein in different lymphoid cells under normal physiological conditions remain largely unknown.

In a screen designed to identify genes that regulate T cell receptor (TCR)/CD3-mediated apoptosis, we found that high level expression of CD43 protected T cell hybridomas from activation-induced cell death.

The fact that expression of the CD43 dominant negative mutant, reduction of CD43 expression or inhibition of the PI3K/AKT pathway all impaired cell migration, suggests that CD43 signaling is also modulating the Merlin-mediated regulation of cell migration.

As a potential candidate, CD43, also known as leukosialin or sialoglycoprotein, has been shown to be expressed on early hematopoietic cells derived from hESCs [4, 14]. Comparable to CD34, CD43 is a strongly glycosylated transmembrane sialomucin, expressed on all hematopoietic cells, except mature erythrocytes [15].