Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain.

2001年4月1日 · In this study, we have shown that CD41 antigen is expressed on a fraction of LTC-ICs and NOD-SCID reconstituting cells as well as on cells with a B-, T-, and natural killer (NK)–lymphoid potential derived from cord blood cells.

2011年5月12日 · CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated.

2013年5月30日 · Integrin CD41, thought to absent on adult HSCs, marks a novel subset of myeloid-biased long-term HSCs that becomes prevalent with age. Loss of CD41 leads to transplantable hematopoietic defects that affect HSC survival and maintenance and are, in part, mediated by platelet loss.

In clonogenic assays, more than 80% of all progenitors (megakaryocytic, granulo-macrophagic, erythroid and pluripotent) derived from embryoid bodies expressed the CD41 antigen. CD41 was the most reliable marker of early steps of hematopoiesis.

CD41 (integrin αIIb) is known to be expressed by platelets and hematolymphoid cells. We identified two distinct populations of CD41 + Lyve1 + and CD41 + Lyve1-cells in the LNs. CD41 + Lyve1-cells appear in the LN mostly at the later stages of the lives of mice.

2013年5月30日 · Here we show that platelet integrin CD41 (αIIb), currently thought to only transiently mark fetal HSCs, is expressed on an adult HSC subtype that accumulates with age.

We demonstrate that CD41 serves as the earliest marker of primitive erythroid progenitor cells in the embryonic day 7 (E7.0) yolk sac and high-level expression identifies essentially all E8.25 yolk sac definitive hematopoietic progenitors.

The α IIb integrin subunit (CD41) is one of the first cell surface markers indicative of hematopoietic commitment. α IIb pairs exclusively with β 3 to form the α IIb β 3 integrin. β 3 (CD61) also pairs with α v (CD51) to form the α v β 3 integrin.

CD41 (or integrin αIIb) is a marker of the megakaryocytic lineage and also of other clonogenic progenitors. 1–5 CD41 marks the onset of murine primitive and definitive hematopoiesis. 5–9 At embryonic day 7 (E7), yolk sac (YS) primitive erythroid progenitors express low levels of CD41. 7 By E8.25/E9.5, most YS definitive hematopoietic ...