Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 on T H cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

2024年12月24日 · CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Agammaglobulinemia, X-Linked. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

3 天之前 · Without proper CD40-CD40L engagement, germinal center responses are impaired, weakening long-term humoral immunity. CD40 signaling also influences whether B cells differentiate into memory B cells or plasma cells. The strength and duration of CD40 stimulation regulate transcription factors such as Bcl-6 and Blimp-1, which determine B cell fate.

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type.

2008年11月1日 · CD40 has a rich history as a prominent immune cell activator. 1 CD40 is best known as the key mediator of B lymphocyte immunoglobulin class switch. It also serves as a major activator of antigen-presenting cells, such as macrophages and dendritic cells.

5 天之前 · CD40 agonist antibodies bind to the CD40 receptor in a highly specific manner, initiating receptor clustering and signal transduction. Unlike CD40L, which engages CD40 in a trimeric configuration, agonist antibodies can be engineered to induce more stable and potent receptor aggregation.

2019年8月5日 · The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications.

2019年5月1日 · Initial results indicate that CD40 on thymic epithelial cells and DC contributes to negative selection of tissue restricted antigen-binding T cells. These results identify different CD40-dependent APC requirements and suggest distinct CD40 signaling pathways for specific immune responses.

CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell death.

2014年1月1日 · CD40 is a type I integral membrane protein and a member of the tumor necrosis factor receptor (TNFR) family of molecules that functions as a major communication link between antigen-presenting cells (APCs) (B cells, macrophage, and dendritic cells (DCs)) and CD4 T cells.