2017年9月8日 · CD30 ligand (CD30L, also known as TNFSF8 or CD153) is a membrane-bound cytokine with sequence homology to other members of the tumor necrosis factor (TNF) family. …

Increased CD30L expression was found on mast cells within HD tumors and preclinical and clinical studies with compounds targeting the CD30/ CD30L system in HD and ALCL …

2024年11月26日 · Results: Analysis of several scRNA-seq datasets from skin lesions of AD patients showed that transcripts for CD30 or CD30L were found expressed with OX40 or …

The results suggest that CD30L/CD30 signaling is involved in the development of both OXA- and TNBS-induced colitis and that the modulation of CD30L/CD30 signaling by mAb could be a …

The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in …

CD30 Ligand is a type II membrane glycoprotein expressed on various immune cells, such as activated T cells, B cells, and macrophages. It plays a role in regulating the growth and …

In this review we consider the reported biology of CD30L and focus on results from several recent studies that point to an important role for CD30/CD30L interactions in humoral immune …

Successful anti-CD30 antibody-drug conjugate (ADC) therapy for HL, ALCL, and PTCL supports the biological significance of CD30 in these lymphomas. In this review, we discuss the roles of …

2015年2月1日 · CD30L/CD30 signaling promotes two-step antigen-specific CD4 T cell responses. Soluble mCD30-Ig treatment before or even after disease onset ameliorates EAE. The CD30 …

In this study, we established an AOM/DSS-induced CAC model with CD30LKO mice to explore the effect of CD30L/CD30 signal transduction on the formation of the intestinal tumor immune …