2022年3月18日 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction (Immunity 2006;24:133, Nature 2019;573:546)

2022年8月29日 · The most common immunophenotype of T cell large granular lymphocytic leukemia is that of mature CD3+ CD8+ T cells expressing NK cell associated markers such as CD16 and CD57 and variable pan T cell marker lost. A) Typical chronic lymphoproliferative disorder of NK cells immunophenotype.

2022年5月2日 · Immunohistochemical studies were performed in bone marrow core biopsy and the T cell marker CD3 highlights lymphocytes in an interstitial and sinusoidal pattern, representing approximately 10% of marrow cells. Atypical lymphocytes are also highlighted with CD2, CD7, CD56, TIA1 and granzyme M.

2023年9月26日 · T lymphocytes Small and round CD3+ and BCL2+ Subset of T helper cells (TFH): polarized CD4+, PD-1 / CD279+, BCL6+, CD10+, CXCL13+, ICOS+ Follicular dendritic cells (FDCs) Few (usually ~1%) 2 square shaped and adjacent nuclei (kissing cells) with vesicular chromatin May display small nucleolus Long cytoplasmic processes

2023年11月7日 · The background small lymphocytes consist mostly of T cells positive for CD3, CD5 and CD45 with approximately equal numbers of CD8+ T cells and CD4+ T cells. The CD21 and CD23 stains are negative for follicular dendritic cell networks.

2025年1月30日 · Most T cell lymphomas and leukemias In ambiguous cases where lymphomas show atypical immunophenotypes, CD5 staining can aid in confirming T cell or B cell origin (Curr Oncol 2021;28:4611) Peripheral T cell lymphomas Both typical and atypical forms of chronic lymphocytic leukemia (95%) (Leuk Lymphoma 1998;31:209)

2021年8月23日 · Comment: CD20 highlights large atypical B cells within small B cell rich nodules. CD3 is positive in background small T cells with occasional CD3 positive T cell rosettes around the large atypical B cells. A PD-1 stain shows T cell rosettes encircling the large atypical B cells in the nodular areas.

2020年1月30日 · A peripheral T cell lymphoma usually consisting of large lymphoid cells with abundant amphophilic cytoplasm, often horseshoe shaped nuclei, an ALK (anaplastic lymphoma kinase) gene translocation and expression of ALK protein and CD30 (Swerdlow: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th Edition, 2017)

40 year old man with primary esophageal extranodal NK / T cell lymphoma, nasal type of biphasic morphology (Medicine (Baltimore) 2015;94:e1151) 50 year old man with extranodal NK / T cell lymphoma, nasal type, presenting with gastrosplenic fistula after chemotherapy (World J Gastroenterol 2017;23:6491)

2025年3月7日 · Peripheral T cell lymphoma, not otherwise specified: T cell lymphoma with expression of T cell markers May show positivity for CD15 or CD30; T cell clonality studies often positive for T cell clone Angioimmunoblastic T cell lymphoma: T cell lymphoma with expression of T cell markers Mixed inflammatory infiltrate