CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

Tebentafusp was approved by the FDA in 2022, is the first-in-class of TCR-ScFv fusion proteins that concomitantly bind CD3 on T cells alongside tumor antigens using affinity-enhanced engineered TCRs to potentiate antitumor immune responses.

2021年1月19日 · CD3+ bispecific T-cell engagers function by redirecting all T-cell populations towards cancer cells to facilitate efficient tumour cell killing.

CD3 is an essential T cell co-receptorand defines T cell lineage. CD3is therefore an ideal T cell marker. This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

CD3 + CD4 - CD8 - double-negative (DN) T cells, although constituting a rare subset of peripheral T cells, are gaining interest for their roles in inflammation, immune disease and cancer. Herein, we comprehensively review the origin, distribution and functions of this unique T cell subgroup.

CD3 + CD20 + T cells are a population of CD3 + T cells co-expressing CD20 that make up to ∼3-5% of the CD3 + T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3 + CD20 + T cells are heterogeneous for contai …

2020年8月20日 · A T cell receptor (TCR) mediates antigen-induced signaling through its associated CD3ε, δ, γ, and ζ, but the contributions of different CD3 chains remain elusive.

4 天之前 · The TCR CD3 complex is essential for T-cell development within the thymus, guiding immature thymocytes through selection processes that determine their functional fate. In the early thymic progenitor stage, CD3 is expressed in complex with the pre-TCR, a temporary receptor composed of a TCR β chain paired with a surrogate pre-Tα chain.

2023年2月13日 · In this review, we summarize the basis of CD3-TCR complex assembly and survey the clinical and preclinical therapeutic tools available to modulate CD3-TCR function for potentiating cancer immunotherapy.

2025年1月15日 · Explore the roles of CD3, CD4, and CD8 in T-cell dynamics and their impact on immune response and signaling. T-cells are a key component of the adaptive immune system, playing a role in identifying and eliminating pathogens.

2022年3月18日 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction (Immunity 2006;24:133, Nature 2019;573:546)

2024年6月7日 · CD3 is a pivotal component of the immune system, playing a crucial role in the activation and function of T cells. Its importance in immune signaling and regulation makes it a key target for therapeutic interventions and a valuable marker in clinical diagnostics.

A commercially available anti-CD3 antibody is polyclonal and reacts with most T-cell lymphomas in fixed tissue, the exceptions being some anaplastic large cell lymphomas and natural killer leukemia/lymphomas. CD3 is specific for T-cell derivation.

CD3 + T cells also play a key role in the resolution of pain after dissipation of peripheral inflammation. In WT mice, complete Freund’s adjuvant (CFA)-induced mechanical hypersensitivity resolves within 2–3 weeks.

2019年3月1日 · CD3 + CD20 + T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3–5% of the CD3 + T-cell compartment in the peripheral blood of human beings.

2023年11月6日 · In the present study, we have systematically engineered new CD3 CARs, each containing only one of the CD3 intracellular domains. We found that CARs containing CD3δ, CD3ε or CD3γ cytoplasmic tails...

2023年2月13日 · The CD3-T cell receptor (TCR) is the canonical receptor complex on T cells. It provides the “first signal” that initiates T cell activation and determines the specificity of the immune response. The TCR confers the binding specificity whilst the CD3 subunits facilitate signal transduction necessary for T cell activation.

Using a novel method for the isolation of intact radiolabeled protein complexes, we demonstrated that the complex assembled in the ER contains only a single TCRαβ heterodimer and one copy of each of the CD3δε, CD3γε and ζ–ζ signaling dimers.

CD3, also known as cluster of differentiation 3, is a protein complex found on the surface of T cells. T cells are a type of white blood cell that play a critical role in the immune system by recognizing and eliminating foreign invaders, such as viruses, bacteria, and cancer cells.

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene. T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. ...

Background CLDN18.2 is a tetraspanin family member, highly expressed in gastric, oesophageal and pancreatic cancer.1 2 CLDN18.2-targeted therapeutic approaches, including combination with chemotherapy, have demonstrated benefit in gastric cancer.3 4 AZD5863 is a CLDN18.2 and CD3-targeting T-cell engager (TCE), designed with high-affinity to human, cynomolgus …

Consistent with endometrial T lymphocyte distribution, the number of fallopian tube CD3+ T cells peaks in the proliferative phase and then decreases following ovulation to low levels in the secretory phase [15]. The FGT contains a number of unique T cell populations.

, The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes., in EMBO J., vol. 10, n. 4, 1991, pp. 903-12, PMC 452733, PMID 1826255.

2025年3月5日 · Naive CD8 + T cells (CD62L + CD44 − CD8 +) were purified by total CD8 + T cells enrichment followed by FACS, as described above and activated by plate-bound anti-CD3 and soluble anti-CD28 (5 µg ...

2025年2月27日 · Nasal anti-CD3 induced a population of interleukin (IL)-10-producing regulatory T cells (T reg cells) that migrated to the brain and closely contacted microglia. T reg cells directly reduced chronic microglia inflammation and regulated their phagocytic function in an IL-10-dependent manner. Blocking the IL-10 receptor globally or specifically ...

6 天之前 · Human T cells were thawed at 10 6 cells/mL and activated with a 3:1 ratio of Human T-expander CD3/CD28 Dynabeads per cell (Life Technologies) in AIM-V medium supplemented with 5% heat-inactivated FBS, 100 U/mL penicillin, 100 U/mL streptomycin, 5 mL GlutaMax, 10mM HEPES, and 40IU/mL IL-2 (R&D Systems). T cells were transduced at an MOI of 2 ...