Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction (Immunity 2006;24:133, Nature 2019;573:546)

May 13, 2021 · Uses by pathologists: T cell marker (membranous staining), although CD3 is more commonly used; marker of systemic mastocytosis Positive staining - normal: Thymocytes (95%), mature peripheral T cells (almost all), NK cells (80 - 90%), mast cells Variable thymic B cells (50%), Langerhans cells Positive staining - disease:

3 days ago · Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). CD45 is positive in nearly all cases and it is an important marker together with other B cell markers (CD20, PAX5, CD19, CD79a, CD75, OCT2 and BOB1) in differentiating classic Hodgkin lymphoma (CHL) …

Jan 17, 2023 · CD10 in diffuse large B cell lymphoma is a marker for germinal center phenotype (also HGAL, BCL6, CD38, LMO2), generally considered a favorable prognostic factor, secondary in part to association with cell of origin classification (germinal center B cell versus activated B cell) (Mod Pathol 2005;18:1113, J Hematop 2009;2:187)

Sep 20, 2021 · Widely used B cell marker (also CD19, CD79a, PAX5) Retained on mature B cells until plasma cell differentiation Anti-CD20 therapy (e.g., rituximab) is available for treatment of non-Hodgkin B cell lymphoma and autoimmune diseases

May 6, 2021 · Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151)

Small B cell initial screening: BCL2 BCL6 CD3 CD20 CD21 Ki67 Refining panel: CD5 CD10 CD23 CD138 cyclin D1 kappa lambda LEF1 SOX11 FISH: CCND1 BCL2 Aggressive B cell initial screening: BCL6 CD3 CD10 CD20 Ki67 MUM1 Refining panel: ALK BCL2 CD5 CD30 CD138 CMYC EBER HHV8 kappa lambda p53 PAX5 FISH: BCL2 BCL6 MYC IRF4 del(11q) T / NK …

Mar 7, 2025 · Immunostains show that the large abnormal cells are positive for PAX5 (weak), CD30 and CD15 (subset) and are negative for CD20, CD45 and CD3. In situ hybridization for EBV encoded RNA (EBER) is negative. CD3 highlights background small T cells. Flow cytometry showed polytypic B cells and mixed T cells subsets.

Jan 1, 2011 · T cell lymphomas have no distinct marker of clonality, but cells may express an abnormal immunophenotype or TCR gene rearrangement As there are only 10 V (variable) regions, a polyclonal population of cells can appear oligoclonal T cell clonality is seen in AIDS and congenital immunodeficiency syndromes, but does NOT indicate malignancy

Apr 19, 2022 · CD3 is incorrect as it is a T cell marker expressed by indolent T lymphoblastic proliferations. CD33 is a myeloid associated marker which has been described as expressed by a subset of indolent T lymphoblastic proliferations. CD45 is a pan-hematopoietic cell marker which is expressed by indolent T lymphoblastic proliferations.