
肿瘤免疫靶点 | CD27 - 知乎 - 知乎专栏
cd27 / cd27l靶点 肿瘤坏死因子受体超家族成员7(TNFRSF7,CD27,由T、B和NK细胞及其前体直接表达)及其唯一已知配体CD27L(TNFSF7,CD70,仅在免疫细胞(树突状细胞DC,B …
肿瘤免疫治疗中的CD27-CD70轴 - 知乎 - 知乎专栏
cd70(cd27l)是cd27的唯一配体,是一种在b淋巴细胞、t淋巴细胞和apc上表达的受严格调控的跨膜糖蛋白。 CD70与其他TNF超家族成员(TNFα、FasL、RANKL、TRAIL、4-1BBL、CD30L …
CD70(CD27L/TNFSF7):TNF受体超家族成员,红斑狼疮、关节 …
2024年3月1日 · cd70/cd27l/tnfsf7是cd27的特异性配体,在相互作用时触发了多种生物学响应。 CD27通过与TRAFs(如 TRAF2 和 TRAF5 )结合,激活NF-kB和c-Jun激酶通路,精准调控 …
CD27 Gene - GeneCards | CD27 Protein | CD27 Antibody
2024年12月24日 · Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B …
CD70-CD27,肿瘤坏死因子TNF家族中的免疫治疗新星 - 健康界
2021年7月12日 · CD27(也称TNFRSF7)是一种跨膜糖蛋白,在CD4+T和CD8+T细胞、自然杀伤 (NK)细胞和胸腺细胞上生理性表达,在priming B细胞上诱导表达,属于肿瘤坏死因子受体超 …
The CD27L and CTP1L Endolysins Targeting - PLOS
2014年7月24日 · The crystal structures presented here for the C-terminal domains of two endolysins that target Clostridia bacteria (CD27L and CTP1L) suggest that CD27L exists in …
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell ... - PubMed
2018年9月19日 · The hexavalent agonist significantly boosted antigen-specific T cell responses while having no effect on non-specific T cells and was superior over stabilized recombinant …
New emerging targets in cancer immunotherapy: CD27 (TNFRSF7)
Cluster of differentiation 27 (CD27) is a member of the tumour necrosis factor receptor superfamily and plays a key role in T-cell activation by providing a costimulatory signal.
HERA-CD27L (HERA-CD27L) - 药物靶点:CD27_在研适应症:肿 …
HERA-CD27L: 一种CD27刺激剂药物,由Apogenix AG (Apogenix AG)公司最早进行研发,目前全球最高研发状态为临床前,作用机制: CD27刺激剂(CD27抗原刺激剂),治疗领域: 肿瘤,在研 …
A Comprehensive Pan-cancer Analysis of the Biological ... - PubMed
2024年1月1日 · The CD27/CD27L axis is its pathway of action. Therefore, our goal was to examine the predictive role of CD27 in the clinical prognosis of 33 cancer types and its …