Integrin beta 2 - Wikipedia
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. [5] Upon binding with one of a number of alpha chains, CD18 is …
The role of CD18 in the production and release of neutrophils …
Neutrophil numbers must be tightly controlled to maintain host protection and prevent neutrophil-mediated tissue injury. CD18 deficiency leads to neutrophilia and myeloid hyperplasia in the …
CD18 - an overview | ScienceDirect Topics
C CD11b/CD18. CD11b/ CD18 is a member of the leukocyte integrin family of heterodimeric adhesion molecules, which consist of a common β-subunit and a unique α-subunit. Wright and …
LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate …
Apr 9, 2019 · The integrins LFA-1(CD11a/CD18) and Mac-1(CD11b/CD18) play overlapping roles in neutrophil migration because they bind the same as well as different ligands in response to...
β2 Integrin CD11d/CD18: From Expression to an Emerging
Nov 7, 2021 · CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known CD11d adhesive mechanisms contribute to both extravasation and mesenchymal...
Leukocyte CD11/CD18 integrins: biological and clinical relevance
The CD11/CD18 integrins are differentiated antigens which play a critical role in this mechanism. CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. …
The role of CD18 in the production and release of neutrophils
Feb 8, 2010 · These studies examined the function of CD18 in regulating neutrophil production and determined whether the defects in neutrophil production that are observed in CD18 …
CD18 – Knowledge and References – Taylor & Francis
CD18 is a subunit of the β2 integrin family and a leukocyte adhesion molecule that plays a crucial role in immune function. It is unique among integrins for its structure and function and is …
CD18 - an overview | ScienceDirect Topics
CD18 is a 95 kDa glycoprotein that is a subunit of LFA-1. It consists of extracellular, transmembrane, and cytoplasmic domains, with potential glycosylation sites and cysteines for …
T Cell-Extrinsic CD18 Attenuates Antigen-Dependent CD4
May 1, 2015 · The β 2 integrins (CD11/CD18) are heterodimeric leukocyte adhesion molecules expressed on hematopoietic cells. The role of T cell-intrinsic CD18 in trafficking of naïve T …