Los Angeles, CA – Councilwoman Monica Rodriguez has established a temporary relief fund for service sector workers in Council District 7 whose incomes were impacted by the January wild fires,…

CD7 (C luster of D ifferentiation 7) is a protein that in humans is encoded by the CD7 gene. [5] This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells.

Dec 24, 2024 · CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Mycosis Fungoides and Lymphoblastic Lymphoma. Among its related pathways is Innate Lymphoid Cells Differentiation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity.

CD7分子是人体免疫细胞膜上一类重要的表面标志物，在淋巴细胞发育成熟过程中发挥协同刺激分子受体的作用。 CD7分子作为血液系统恶性疾病的肿瘤细胞表面的异常标志物，在急性T淋巴细胞白血病 (T-ALL)、T细胞淋巴瘤中呈高表达，约30%急性髓细胞白血病 (AML)患者的肿瘤细胞中，可检测到CD7抗原表达。 CD7分子被认为与疾病侵袭性、耐药性及不良预后有关。 强效化疗、免疫治疗、造血干细胞移植 (HSCT)等治疗方案对血液系统恶性疾病的治疗已取得显著成效。 尽管 …

Aberrant phenotype expression in acute myeloid leukemia (AML) may be due to genetic defects and is associated with a poor prognosis. CD7 is the first T-cell-associated antigen to be expressed during T-lymphocyte maturation. Aberrant expression of CD7 in AML influences clinical response, remission rate, and overall survival in these patients.

CD7 is a transmembrane glycoprotein and a member of the immunoglobulin supergene family. You might find these chapters and articles relevant to this topic.

CD7 is a single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells.

Mar 1, 2003 · CD7 identifies three populations of CD8 T cells: CD7 high (CD7 (high)), low (CD7 (low)), and negative (CD7 (neg)) that translate into subsets with distinct functional properties. The CD7 (high) subset contains naive and memory cells and the CD7 (low) and CD7 (neg) subsets contain effector cells.

Jan 2, 2019 · Here, we show that expression of a CD7-directed CAR in CD7 gene-edited (CD7 KO) T cells effectively eliminates CD7 + AML cell lines, primary CD7 + AML, and colony-forming cells but spares myeloid and erythroid progenitor cells and their progeny. In a xenograft model, CD7 CAR T cells protect mice against systemic leukemia, prolonging survival.

Apr 25, 2023 · CD7 is an ideal target for T-cell malignancies but is also expressed on normal T cells, which may cause CAR-T cell fratricide. Donor-derived anti-CD7 CAR-T cells using endoplasmic reticulum...