
CCL3 - Wikipedia
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes [6] through binding to the receptors CCR1, CCR4 and CCR5.
Macrophage Inflammatory Protein-1 Alpha (MIP-1 alpha)/CCL3: …
Macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) is a chemotactic chemokine secreted by macrophages. It performs various biological functions, such as recruiting inflammatory cells, wound healing, inhibition of stem cells, and maintaining ...
CCL3 Signaling in the Tumor Microenvironment - PubMed
CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.
CCL3 - an overview | ScienceDirect Topics
CCL3, also known as macrophage inflammatory protein 1α (MIP-1α), induces inflammatory cytokines to specific sites by binding to the CCR1/3/9 receptors (Li et al., 2020). CCL3 is mainly produced by mononuclear macrophages, lymphocytes, and neutrophils, but can also be produced by …
CCL3 C-C motif chemokine ligand 3 [ (human)] - National Center …
CCL3 promotes VEGF-A expression and angiogenesis in human osteosarcoma cells by down-regulating miR-374b expression via JNK, ERK, and p38 signaling pathways. The residues on the N-loop and beta-sheets of MIP-1a are close to both CCR1 and CCR5, and those in the C-terminal helix region are close to CCR5.
CCL3 Gene - GeneCards | CCL3 Protein | CCL3 Antibody
2024年12月24日 · CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Aseptic Meningitis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.
CCL3 protein expression summary - The Human Protein Atlas
Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. The RNA data was used to cluster genes according to their expression across cell lines.
Enriching CCL3 in the Tumor Microenvironment Facilitates T cell ...
CCL3, also known as macrophage inflammatory protein 1-alpha, is a cytokine belonging to the CC chemokine family. CCL3 is released when CD4 + T cells interact with DCs and recruit CCR5-expressing CD8 + T cells into specific sites for in vivo activation and proliferation (24,25).
CCL3 Promotes Cutaneous Wound Healing Through Recruiting …
Inflammation is the first step; thus, immune factors play an important regulatory role in wound healing. In this study, we focused on a chemokine, C-C motif chemokine ligand 3 (CCL3), which is often upregulated for expression during wound healing.
The Chemokine CCL3 Regulates Myeloid Differentiation and
2018年10月2日 · The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression.