2021年10月15日 · The effectiveness of broad-spectrum caspase inhibitors Z-VAD-FMK and M920, and selective caspase-3 inhibitor M791 in blocking lymphocyte apoptosis and improving …

2006年9月8日 · This review specifically looks at caspase inhibitors as distinct from caspase regulators: those produced by the cell itself; those whose genes are carried by viruses; and …

2021年10月15日 · Multiple caspase inhibitors have been designed and synthesized as a potential therapeutic tool for the treatment of cell death-related pathologies.

The dipeptidyl general caspase inhibitor 125 I-M808 (iodotyrosyl-VD-FMK) was used to show radiolabeling of caspases in tissues from animals following apoptotic challenges (Methot et al. …

Multiple caspase inhibitors have been designed and synthesized as a potential therapeutic tool for the treatment of cell death-related pathologies.

Z-VAD-FMK is a cell-permeable pan-caspase inhibitor [1, 2]. It potently inhibits human caspase-1 to -10 with the exception of caspase-2 [3]. It also inhibits murine caspases, notably caspase-1, …

Caspase inhibitors are attractive hepatoprotective drugs for the treatment of human liver diseases. The broad irreversible caspase inhibitor Z-VAD-fmk showed a protective effect by blocking …

2025年3月15日 · Research into caspase-3 inhibitors aims to regulate apoptotic pathways to prevent unnecessary cell loss while addressing safety concerns. Understanding how these …

This review describes the later direct caspase inhibitors that have been identified, products of both viral and cellular genes, and artificial caspase inhibitors that have been developed both as …

INHIBITORS OF CASPASES. Caspase inhibitors are available as either pan-caspase or caspase-specific inhibitors. Depending on the assay used to measure apoptosis, these inhibitors will not …