2017年8月31日 · Formed by the process of chondrogenesis, the resulting chondrocytes are capable of producing large amounts of collagenous extracellular matrix and ground substance, which together form cartilage itself. This article explains the structure, composition, formation and histology of cartilage.

The cartilage matrix consists of macromolecules in which collagen and proteoglycans (aggrecan) are the main representatives. These components are highly ordered from the cartilage surface to the deepest layers.

The matrix of cartilage acts as a barrier, preventing the entry of lymphocytes or diffusion of immunoglobulins. This property allows for the transplantation of cartilage from one individual to another without fear of tissue rejection.

2022年10月17日 · The cartilage matrix consists of fibrous tissue and various combinations of proteoglycans and glycosaminoglycans. Cartilage, once synthesized, lacks lymphatic or blood supply, and the movement of waste and nutrition is chiefly done …

Articular cartilage is hyaline cartilage and is 2 to 4 mm thick. Unlike most tissues, articular cartilage does not have blood vessels, nerves, or lymphatics. It is composed of a dense extracellular matrix (ECM) with a sparse distribution of …

The cartilage matrix comprises a network of collagen fibrils enmeshed in a concentrated PG solution. The collagen and PGs interact to form a porous composite fiber-reinforced organic solid matrix that is swollen with water (Mow and Hung, 2001).

2023年7月17日 · There are two main cell types in cartilage: The chondroblasts are found near the outer surface of the cartilage, under the perichondrium, and these secrete the extracellular matrix. As they do this, they become entrapped and mature into chondrocytes.

2023年4月17日 · Chondrocytes maintain the extracellular matrix (ECM) and produce the cartilage matrix. Surrounded by collagenous fibers, chondrocytes release substances to make cartilage strong yet flexible. In general, chondrocytes are found within intervertebral discs and in any form of articular cartilage (AC).

Know the major components of cartilage matrix and understand how they are responsible for cartilage resilience. Understand the two types of cartilage formation in adults (appositional and interstitial growth) and the role of mesenchymal stem cells in the perichondrium.

In this review, we focus on the important role of volume control-related ion channels in cartilage matrix remodeling and summarize current views. In addition, the potential mechanism of the volume-sensitive anion channel LRRC8A in the early occurrence of osteoarthritis is discussed.