Carbapenems are a class of beta-lactam antibiotic that are active against many aerobic and anaerobic gram-positive and gram-negative organisms. Thienamycin was the first carbapenem to be discovered in 1976.

Carbopenems are a class of drugs used to treat a wide variety of bacterial infections (including Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloaca) of the skin, lungs, stomach, pelvis, urinary tract, and kidneys.

Carbapenems display broad-spectrum activity against Gram-negative bacteria and slightly reduced activity against Gram-positive infections. Meropenem is often used to target serious hospital-acquired infections of unknown aetiology.

2011年8月22日 · Carbapenems play a critically important role in our antibiotic armamentarium. Of the many hundreds of different β-lactams, carbapenems possess the broadest spectrum of activity and greatest potency against Gram-positive and Gram-negative bacteria.

Carbapenems are parenteral bactericidal beta-lactam antibiotics that have an extremely broad spectrum. They are active against. Most Enterococcus faecalis and many Pseudomonas aeruginosa strains, including those resistant to broad-spectrum penicillins and cephalosporins, are susceptible to imipenem and meropenem but are resistant to ertapenem.

Carbapenems are a subclass of antibiotics called beta-lactam antibiotics (antibiotics that have a chemical structure called a beta-lactam ring). Beta-lactam antibiotics also include cephalosporins, monobactams, and penicillins. Carbapenems are broad-spectrum antibiotics.

2023年5月11日 · Carbapenems are members of the β-Lactam antibiotic class. Molecularly defining, carbapenems are antibiotics having β– lactam ring with sulfur at the C-1 position and a double bond between C-2 and C-3 of the ring with the side chains arranged in the Trans- position.

We describe the initial discovery and development of the carbapenem family of β-lactams. Of the early carbapenems evaluated, thienamycin demonstrated the greatest antimicrobial activity and became the parent compound for all subsequent carbapenems.

The carbapenems are beta-lactam antibacterials with a broad-spectrum of activity which includes many Gram-positive and Gram-negative bacteria, and anaerobes; imipenem (imipenem with cilastatin) and meropenem have activity against Pseudomonas aeruginosa but emerging acquired resistance can be a problem.

2025年1月10日 · Carbapenems are a class of antibiotics essential in modern medicine due to their broad-spectrum efficacy against various bacterial infections. They are particularly valuable in treating severe or high-risk bacterial infections when other antibiotics fail.