Calu-3 is a cell line obtained from a male, lung adenocarcinoma patient that can be used in cancer and toxicology research.

This article reviews the application of the human airway Calu-3 cell line as a respiratory model for studying the effects of gas concentrations, exposure time, biophysical stress, and biological agents on human airway epithelial cells.

2020年10月22日 · Calu-3 cells are a submucosal gland cell line, which was generated from a bronchial adenocarcinoma. Under air–liquid interface conditions Calu-3 cells grow in monolayers, producing mucus and cilia-like microvilli.

Calu-3 is a non-small-cell lung cancer cell line that grows in adherent culture and displays epithelial morphology. These cells have constitutively active ErbB2/Her2 due to amplification of the ERBB2 gene.

Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

The Calu-3 tumor model is a well-established xenograft model to study the effects therapeutics, such as erlotinib, trastuzumab and pertuzumab on HER2 and EGFR expressing cells. Calu-3 xenografts are commonly used to investigate the effects of various drugs and compounds on tumor growth and metastasis.

Calu-3 cells constitute a human-derived airway epithelial cell line representing non-small cell lung carcinoma. They are widely used in biomedical research that includes studying lung cancer biology, respiratory diseases, host-pathogen interactions, and drug transport in the airway.

The Calu-3 CDX mouse model enables investigation of human lung cancer cell therapeutics targeting migration, apoptosis, anti-angiogenesis and anti-tumor growth in a human-similar tumor environment. Such tumor growth delay studies include the combination studies of erlotinib and cetuximab, or trastuzumab and pertuzumab.

The Calu-3 cell line can assist in finding potential drug therapies and has shown to be useful in mimicking in vivo conditions.3 This similarity has allowed for many pharmaceutical applications such as drug transport, studying aerosol deposition, controlled release studies, and identification of potential drug-drug interactions.4 The ...

Calu-3 Human Lung Adenocarcinoma Cell Line The characteristics of Calu3 cell line allow for a basic in vitro method of developing new therapeutics in an epithelial respiratory model. - Find MSDS or SDS, a COA, data sheets and more information.