Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene. [5] [6] Calreticulin is a multifunctional soluble protein that binds Ca 2+ ions (a second messenger in signal transduction), rendering them

Calreticulin plays a role of ER luminal Ca 2+ sensor to manage Ca 2+ ‐dependent ER luminal events including maintaining interaction with its partners, Ca 2+ handling molecules, substrates and stress sensors.

2020年7月30日 · Calreticulin (CALR) is a Ca 2+-binding endoplasmic reticulum (ER) protein that aids the folding of proteins destined to secretion and insertion in the plasma membrane, de facto providing a major...

1997年2月21日 · Calreticulin is an abundant 46 kDa, high capacity Ca 2+-binding protein found (with the exception of erythrocytes) in every cell of higher organisms.

Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important functions in directing proper conformation of proteins and glycoproteins, as well as in homeostatic control of cytosolic and ER calcium levels.

Calreticulin is recognized as a multifunctional protein that serves an essential role in diverse biological processes that include wound healing, modification and folding of proteins, regulation of the secretory pathway, cell motility, cellular ...

2023年6月26日 · Calreticulin is a quintessential multifaceted protein performing diverse functions at multiple locations in the cell. Significance of its varied physiological roles and implications of its dysregulation along with its diagnostic and therapeutic potential has been presented in …

2009年2月1日 · Calreticulin is an ER (endoplasmic reticulum) luminal Ca2+-buffering chaperone. The protein is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. The protein impacts on store-operated Ca2+ influx and influences Ca2+-dependent transcriptional pathways during embryonic dev …

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca 2+ buffer to assist correct protein folding within the ER.

Calreticulin is a Ca 2+ binding/storage chaperone resident in the lumen of endoplasmic reticulum (ER). The protein is an important component of the calreticulin/calnexin cycle and the quality control pathways in the ER. In mice, calreticulin deficiency …