Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates [5] in the ultimopharyngeal body. [6] It acts to reduce blood calcium (Ca 2+), opposing the …

calcitonin, a protein hormone synthesized and secreted in humans and other mammals primarily by parafollicular cells (C cells) in the thyroid gland. In birds, fishes, and other nonmammalian vertebrates, calcitonin is secreted by cells of the glandular ultimobranchial bodies.

2010年1月1日 · Calcitonin is synthesized by the parafollicular cells (C-cells) of the thyroid gland in mammals 2., 3., 5., 6. and by the C-cells associated with the ultimobranchial gland in lower vertebrates 7., 8..

2023年8月17日 · Calcitonin is a peptide hormone consisting of 32 amino acids, primarily synthesized by the parafollicular cells (C cells) of the human thyroid gland. The hormone exists in different forms, including salmon calcitonin, human calcitonin, and synthetic analog.

Calcitonin is a 32 amino acid peptide hormone, secreted from the parafollicular cells of the thyroid gland in response to increased blood calcium concentration (Potts, 1992). Calcitonin antagonises PTH and protects against development of acute hypercalcaemia (Rodriguez et al., 1991).

We have carried out studies to determine whether calcium and dibutyryl cyclic AMP influence synthesis as well as release of calcitonin. For this purpose slices of porcine thyroid tissue were...

Calcitonin structure, biological activity, formation in organism and methods of production including isolation from natural sources, chemical synthesis and genetic engineering methods are reviewed.

2021年8月24日 · In contrast to parathyroid hormone, increases the excretion of calcium, phosphate, sodium, potassium, and magnesium and inhibits the synthesis of 1,25-dihydroxycholecalciferol. The third and most prolonged effect of calcitonin is to decrease the formation of new osteoclasts.

This review summarises some key aspects of its synthesis, structure and its actions at the cellular and molecular levels, and leads on to its therapeutic uses that have emerged since its discovery as well as possibilities for future clinical applications.

2006年9月29日 · This chapter summarizes major concepts in the synthesis and structure of calcitonin and then proceeds to outline its cellular, molecular actions and therapeutic applications, whilst seeking to provide a reference source.

Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal tract.

Synthesis of Calcitonin. Calcitonin is biosynthesised by the proteolytic cleavage of prepropeptide that is released from the CALC1 gene. It functions antagonistically to vitamin D3 and parathyroid hormone. The synthesis or secretion of calcitonin is triggered by high levels of calcium in blood and the presence of pentagastrin and gastrin.

2012年1月1日 · In mammals, the major site of calcitonin synthesis is the parafollicular cells of the thyroid, which secrete calcitonin in response to an increase in plasma calcium concentration and in response to a number of gut hormones, including gastrin and glucagon.

Calcitonin’s potent antiresorptive effect has led to its use in treating Paget’s disease of bone, osteoporosis, and hypercalcemia. This review retraces key aspects of the synthesis and structure of calcitonin, its cellular and molecular actions, and its therapeutic uses as they have emerged over the 40 years since its discovery.

While studying the control of its secretion in 1961, we discovered a second calcium-regulating hormone (calcitonin) which was released by hypercalcemia and lowered plasma calcium by inhibiting osteolysis.

Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium ...

Calcitonin is a 32-amino acid polypeptide hormone of thyroid origin discovered by Copp in 1961 [1] who described it as regulating the plasma calcium concentration, or “tone.” Calcitonin is produced by the parafollicular “C” cells of the thyroid [1], which originate in the neural crest.

2025年1月7日 · Calcitonin’s main job is to lower calcium levels in your blood (not your bones). It does this in two main ways: Calcitonin blocks the activity of osteoclasts, which are cells that break down bone. When osteoclasts break down your bone, the …

Calcitonin’s potent antiresorptive effect has led to its use in treating Paget’s disease of bone, osteoporosis, and hypercalcemia. This review retraces key aspects of the synthesis and structure of calcitonin, its cellular and molecular actions, and its therapeutic uses as they have emerged over the 40 years since its discovery.

2023年7月31日 · How is Calcitonin Synthesized? Calcitonin is synthesized through the proteolytic cleavage of a prepropeptide that is encoded by the CALC1 gene. It works against vitamin D3 and parathyroid hormone . The production or secretion of calcitonin is triggered by elevated levels of calcium in the bloodstream and the presence of pentagastrin and gastrin.