2025年2月19日 · CADASIL is an autosomal dominant trait, with patients typically becoming symptomatic in adulthood (30 to 50 years of age). Clinical presentation. Presentation is usually with recurrent transient ischemic attacks (TIAs) or strokes in multiple vascular territories. Presenile dementia and migraines develop in the third-to-fourth decades of life.

MRI findings of CADASIL include symmetric T2 hyperintensities in the periventricular/deep white matter, basal ganglia, and brainstem structures. Presence of these MRI patterns as well as a family history of a similar clinical picture should raise suspicion of CADASIL and mitigate potentially dangerous misdiagnoses.

CADASIL or Multiple Sclerosis? CADASIL Update 2017; Clinical Checklist; For Psychiatrists; MRI; The CADASIL Scale; When To Suspect CADASIL

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL): A Rare Cause of Transient Ischemic Attack.

Been diagnosed with CADASIL? This site helps you, your family and your doctor understand what Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is and how it. Includes links to a range of other …

Magnetic resonance imaging (MRI) is a central component of the diagnosis and monitoring of CADASIL. Here we provide a descriptive review of the literature on three important aspects pertaining to the use of MRI in CADASIL. First, we review past research exploring MRI markers for this disease.

1999年2月1日 · Background —We recently showed that the severity of MRI signal abnormalities increases with age in CADASIL, an arteriopathy due to mutations of notch 3 gene on chromosome 19. Previous results also suggest that the various hemispheric subcortical areas have a different vulnerability to ischemia in this disease.

2002年11月7日 · Background and Purpose— In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a large increase in water diffusion has been found both inside and outside the cerebral lesions as detected on conventional MRI.

2024年2月3日 · CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a genetic small-vessel disease typically seen in adults, characterised by the NOTCH3 gene mutation, accumulation of granular osmiophilic material, and white matter hyperintensities on T2-weighted and FLAIR MRI.

We aimed to develop and validate a simple tool to inventory quickly the key MRI features in CADASIL to compare imaging data across different populations. The Inventory Tool (CADA-MRIT) was designed by consensus after repeated expert meetings.